Abstract:
:Proteins governing cell death form the basis of many normal processes and contribute to the pathogenesis of many diseases when dysregulated. Here we report the cloning of a novel human CED-4-like gene, CLAN, and several of its alternatively spliced isoforms. These caspase-associated recruitment domain (CARD)-containing proteins are expressed at varying degrees in normal human tissues and may contribute to a number of intracellular processes including apoptosis, cytokine processing, and NF-kappa B activation. The CARD of the CLAN proteins binds a number of other CARD-containing proteins including caspase-1, BCL10, NOD2, and NAC. Once their physiologic functions are uncovered, CLAN proteins may prove to be valuable therapeutic targets.
journal_name
Genomicsjournal_title
Genomicsauthors
Damiano JS,Stehlik C,Pio F,Godzik A,Reed JCdoi
10.1006/geno.2001.6579subject
Has Abstractpub_date
2001-07-01 00:00:00pages
77-83issue
1-3eissn
0888-7543issn
1089-8646pii
S0888-7543(01)96579-6journal_volume
75pub_type
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