Abstract:
:RFX1 is a transacting DNA-binding regulatory factor involved in the control of MHC class II gene expression. RFX2 is a structurally very similar protein with identical DNA binding features. A member of the family of RFX factors is affected in an autosomal recessive disease, MHC class II deficient combined immunodeficiency (CID), caused by a defect in a trans-acting regulatory factor controlling MHC class II gene expression. In situ hybridization with 3H-labeled RFX1 cDNA has allowed us to identify two distinct targets on the short arm of chromosome 19 (19p13.1 and 19p13.2-p13.3). With the use of biotinylated genomic cosmid clones specific for RFX1 and RFX2, respectively, it was then possible to localize RFX1 at 19p13.1 and RFX2 at 19p13.2-p13.3. These two regulatory genes are thus assigned to a region of high gene density and RFX1 is close to another DNA-binding factor, LYL1.
journal_name
Genomicsjournal_title
Genomicsauthors
Pugliatti L,Derré J,Berger R,Ucla C,Reith W,Mach Bdoi
10.1016/0888-7543(92)90052-tsubject
Has Abstractpub_date
1992-08-01 00:00:00pages
1307-10issue
4eissn
0888-7543issn
1089-8646journal_volume
13pub_type
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