Abstract:
:The recessive male sterility and histoincompatibility (mshi) mutation in the mouse generates pleiotropic effects on histocompatibility and male reproduction, while female mutants appear to be reproductively normal. We have mapped the mshi mutation to mouse Chromosome (Chr) 10 by analysis of 126 progeny from an intraspecific backcross. Our analysis both places the male sterility and histoincompatibility controlled by mshi within a 20-cM interval between the markers D10Mit51/D10Mit212 and D10Mit170 and has allowed the ordering of several other microsatellite markers on Chr 10 that were previously unresolved. The high-resolution backcross panel we describe should facilitate the isolation of more tightly linked probe sequences and, ultimately, the molecular identification of the gene or genes affected by this interesting mutation.
journal_name
Genomicsjournal_title
Genomicsauthors
Turner JP,Carpentino JE,Cantwell AM,Hildebrandt AL,Myrie KA,King TRdoi
10.1006/geno.1996.4475subject
Has Abstractpub_date
1997-01-01 00:00:00pages
1-7issue
1eissn
0888-7543issn
1089-8646pii
S0888-7543(96)94475-4journal_volume
39pub_type
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