Abstract:
:The human UBE2L3 gene encodes the ubiquitin-conjugating enzyme UbcH7, demonstrated to participate in the ubiquitination of p53, c-Fos, and NF-kappaB in vitro. We report the fine-mapping of this four-exon gene to chromosome 22q11.2. We have constructed a comprehensive genomic clone contig across this gene, demonstrating that the gene lies adjacent to the microsatellite marker D22S446 and spans approximately 57 kb. Four mRNA species are transcribed from this gene, differing in the length of their 3' UTR. Sequence comparison of the UBE2L3 cDNA with its murine homologue reveals a remarkably high degree of sequence conservation within the 3'UTR.
journal_name
Genomicsjournal_title
Genomicsauthors
Moynihan TP,Cole CG,Dunham I,O'Neil L,Markham AF,Robinson PAdoi
10.1006/geno.1998.5257subject
Has Abstractpub_date
1998-07-01 00:00:00pages
124-7issue
1eissn
0888-7543issn
1089-8646pii
S0888-7543(98)95257-0journal_volume
51pub_type
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