The gene for the human putative apoE receptor is on chromosome 12 in the segment q13-14.

Abstract:

:We have previously described the cDNA coding for a new lipoprotein receptor that contains domains closely related to the ligand-binding domain of the LDL receptor. We have now investigated the localization of the gene for this new receptor by hybridization of the cDNA to panels of rodent cells containing subsets of human chromosomes and by in situ hybridization of the cDNA to chromosomes. The gene maps to 12q13-14, a known hot spot for chromosomal rearrangements in human neoplasia. Of particular interest is the frequent involvement of the 12q13-14 segment in clonal abnormalities in lipomas and myxoid liposarcomas, and it is possible that LRP may play a role in the pathogenesis of such tumors.

journal_name

Genomics

journal_title

Genomics

authors

Myklebost O,Arheden K,Rogne S,Geurts van Kessel A,Mandahl N,Herz J,Stanley K,Heim S,Mitelman F

doi

10.1016/0888-7543(89)90087-6

subject

Has Abstract

pub_date

1989-07-01 00:00:00

pages

65-9

issue

1

eissn

0888-7543

issn

1089-8646

journal_volume

5

pub_type

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