Abstract:
:Cardiovascular disease (CVD) is an important cause of disease-related death worldwide. One of its main pathological bases is imbalances in gene expression. Non-coding RNAs are a class of transcripts that do not encode proteins. They include microRNA (miRNA), long noncoding RNA (lncRNA) and circular RNA (circRNA). They have important biological functions such as regulating transcription and translation, as well as interacting with DNA, RNA, and proteins. They are also closely associated with pathological processes in CVD. This review will focus on the expression and function of miRNA, lncRNA, circRNA, as well as on their roles and molecular mechanisms in CVDs such as cardiac hypertrophy, heart failure, arrhythmia, myocardial infarction, atherosclerosis, rheumatic heart disease, myocardial fibrosis, pulmonary arterial hypertension. This review will outline concepts provide bases for early diagnosis and targeted treatment of CVDs.
journal_name
Genomicsjournal_title
Genomicsauthors
Zhu L,Li N,Sun L,Zheng D,Shao Gdoi
10.1016/j.ygeno.2020.10.024subject
Has Abstractpub_date
2020-10-22 00:00:00eissn
0888-7543issn
1089-8646pii
S0888-7543(20)31983-2pub_type
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