Abstract:
:Six of the human minisatellites detected by DNA fingerprint probes have been localized by in situ hybridization to human metaphase chromosomes. These hypervariable loci are not dispersed at random in the human genome, but show preferential, though not exclusive, localization to terminal G-bands of human autosomes. Two of the proterminal minisatellites are very closely linked to other variable loci. Sequence analysis of one of these additional minisatellites suggests that the two linked minisatellites arose by independent amplification of different repeat units. The proterminal regions of human autosomes may therefore be rich in minisatellites, analogous to the pseudoautosomal terminal pairing region of human sex chromosomes that is similarly abundant in hypervariable minisatellites.
journal_name
Genomicsjournal_title
Genomicsauthors
Royle NJ,Clarkson RE,Wong Z,Jeffreys AJdoi
10.1016/0888-7543(88)90127-9subject
Has Abstractpub_date
1988-11-01 00:00:00pages
352-60issue
4eissn
0888-7543issn
1089-8646journal_volume
3pub_type
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