Abstract:
:A human tryptophan oxygenase clone was isolated by screening a liver cDNA library with a rat tryptophan oxygenase cDNA clone. Analysis showed extensive homology between the rat and the human DNA and protein sequences. The combined use of cell hybrids and in situ hydridization indicated that human tryptophan oxygenase was localized to chromosome band 4q31. The tryptophan oxygenase gene may be important in some human behavior disorders, especially those associated with abnormalities of serotonin metabolism.
journal_name
Genomicsjournal_title
Genomicsauthors
Comings DE,Muhleman D,Dietz GW Jr,Donlon Tdoi
10.1016/0888-7543(91)90257-fsubject
Has Abstractpub_date
1991-02-01 00:00:00pages
301-8issue
2eissn
0888-7543issn
1089-8646pii
0888-7543(91)90257-Fjournal_volume
9pub_type
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