Linkage analysis in familial adenomatous polyposis: order of C11P11 (D5S71) and pi 227 (D5S37) loci at the apc gene.

Abstract:

:Linkage analysis with DNA probes C11P11 and pi 227 is reported in six Scottish families with familial adenomatous polyposis. Two families were informative for C11P11 and all six were at least partly informative for pi 227. Two C11P11-apc and two pi 227-apc recombinants were identified and one of these was recombinant for both C11P11-apc and pi 227-apc. A further possible combined C11P11-apc and pi 227-apc recombination event was also identified. Peak lod score for linkage of C11P11 to apc was 5.80 at a recombination fraction (theta) of 0.069 (95% probability limits 0.012-0.191) and for linkage of pi 227 to apc was 3.19 at theta = 0.110 (95% probability limits 0.023-0.286). Peak lod score for linkage of C11P11 to pi 227 was 1.79 at theta = 0.00. The data support a gene order of pi 227-C11P11-apc.

journal_name

Genomics

journal_title

Genomics

authors

Dunlop MG,Steel CM,Wyllie AH,Bird CC,Evans HJ

doi

10.1016/0888-7543(89)90068-2

subject

Has Abstract

pub_date

1989-08-01 00:00:00

pages

350-3

issue

2

eissn

0888-7543

issn

1089-8646

pii

0888-7543(89)90068-2

journal_volume

5

pub_type

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