Abstract:
:Linkage analysis with DNA probes C11P11 and pi 227 is reported in six Scottish families with familial adenomatous polyposis. Two families were informative for C11P11 and all six were at least partly informative for pi 227. Two C11P11-apc and two pi 227-apc recombinants were identified and one of these was recombinant for both C11P11-apc and pi 227-apc. A further possible combined C11P11-apc and pi 227-apc recombination event was also identified. Peak lod score for linkage of C11P11 to apc was 5.80 at a recombination fraction (theta) of 0.069 (95% probability limits 0.012-0.191) and for linkage of pi 227 to apc was 3.19 at theta = 0.110 (95% probability limits 0.023-0.286). Peak lod score for linkage of C11P11 to pi 227 was 1.79 at theta = 0.00. The data support a gene order of pi 227-C11P11-apc.
journal_name
Genomicsjournal_title
Genomicsauthors
Dunlop MG,Steel CM,Wyllie AH,Bird CC,Evans HJdoi
10.1016/0888-7543(89)90068-2subject
Has Abstractpub_date
1989-08-01 00:00:00pages
350-3issue
2eissn
0888-7543issn
1089-8646pii
0888-7543(89)90068-2journal_volume
5pub_type
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