Abstract:
:Abnormal histone modifications (HMs) and transcription factors (TFs) can alter the expression of cancer-related genes to promote tumorigenesis. We studied the variations of 11 HMs and 2 TFs in human breast cancer cells (MCF-7) compared to human normal mammary epithelial cells (HMEC), and the effects of HMs/TFs in various regions of the genome on the expression changes of breast cancer-related genes. Based on HMs and TFs signals' differences between MCF-7 and HMEC flanking TSSs, the up- and down-regulated genes in MCF-7 were predicted by Random Forest, and important HMs and regions were found. Results indicate that H3K79me2, H3K27ac, and H3K4me1 are particularly important for the changes of gene expression in MCF-7. Especially, H3K79me2 around the 60-th bin flanking TSSs may be the key for regulating gene expression. Our studies reveal H3K79me2 may be a core HM for breast cancer.
journal_name
Genomicsjournal_title
Genomicsauthors
Jin W,Li QZ,Liu Y,Zuo YCdoi
10.1016/j.ygeno.2019.05.026subject
Has Abstractpub_date
2020-01-01 00:00:00pages
853-858issue
1eissn
0888-7543issn
1089-8646pii
S0888-7543(19)30177-6journal_volume
112pub_type
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