Abstract:
:Despite the increasing number of disorders known to result from trinucleotide repeat amplification, the molecular mechanism underlying these dynamic mutations is still unknown. In an attempt to create a mouse model for the CGG repeat instability seen in Fragile X syndrome, we constructed transgenes corresponding to FMR1 premutation alleles. While in humans these alleles would expand to full mutation with almost 100% certainty upon maternal transmission, they remain stable in our transgenic mice. Therefore, the presence of a large number of uninterrupted CGGs is not sufficient to cause instability in mice, even in the context of flanking human FMR1 sequences.
journal_name
Genomicsjournal_title
Genomicsauthors
Lavedan C,Grabczyk E,Usdin K,Nussbaum RLdoi
10.1006/geno.1998.5299subject
Has Abstractpub_date
1998-06-01 00:00:00pages
229-40issue
2eissn
0888-7543issn
1089-8646pii
S0888-7543(98)95299-5journal_volume
50pub_type
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