Abstract:
:A comparison of the murine and human junB loci reveals nine regions of distal 5'- and 3'-flanking DNA that exhibit greater than 72% sequence identity. A large fraction (over 50%) of the junB locus is contained in these flanking evolutionarily conserved sequences (FECS), which may be required for effecting the proper transcriptional regulation of this gene. Comparative sequence analyses involving kilobases of distal flanking DNAs have been performed for only a small number of vertebrate genes. The available data and the results presented here suggest that FECS may emerge as common yet important functional components of genes, a hypothesis with significant implications for characterizing genes involved in human disease.
journal_name
Genomicsjournal_title
Genomicsauthors
Phinney DG,Tseng SW,Ryder Kdoi
10.1006/geno.1995.1135subject
Has Abstractpub_date
1995-07-20 00:00:00pages
228-34issue
2eissn
0888-7543issn
1089-8646pii
S0888-7543(85)71135-4journal_volume
28pub_type
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