Abstract:
:To study the function of the B cell signal transduction molecule alpha 4 (IGBP1), we isolated a human alpha 4 (IGBP1) gene that has sequence similarity to the yeast protein (TAP42) involved in the rapamycin-sensitive signal transduction pathway. The human alpha 4 has sequence identities with murine alpha 4 of 83.4% nucleotide and 82.9% amino acid sequence, and a stretch of consensus motifs in the carboxyl terminal is conserved among the related genes of human, mouse, yeast, and rice. The gene is expressed as a 1.4-kb mRNA in the spleen, lymph node, thymus, appendix, peripheral blood leukocytes, bone marrow, fetal liver, heart, brain, placenta, skeletal muscle, kidney, and pancreas. The anti-human alpha 4 antibody detected a 45-kDa protein in human lymphoid cell lines. Moreover, human alpha 4 (IGBP1) gene is located at q13.1-q13.3 on chromosome X.
journal_name
Genomicsjournal_title
Genomicsauthors
Onda M,Inui S,Maeda K,Suzuki M,Takahashi E,Sakaguchi Ndoi
10.1006/geno.1997.5048subject
Has Abstractpub_date
1997-12-15 00:00:00pages
373-8issue
3eissn
0888-7543issn
1089-8646pii
S0888754397950485journal_volume
46pub_type
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