Genomic cloning of mouse MIF (macrophage inhibitory factor) and genetic mapping of the human and mouse expressed gene and nine mouse pseudogenes.

Abstract:

:The single functional mouse gene for MIF (macrophage migration inhibitory factor) has been cloned from a P1 library, and its exon/intron structure determined and shown to resemble that of the human gene. The gene was mapped to chromosome 10 using two multilocus crosses between laboratory strains and either Mus musculus musculus or Mus spretus. Nine additional loci containing related sequences, apparently all processed pseudogenes, were also mapped to chromosomes 1, 2, 3, 7, 8, 9, 12, 17, and 19. While most of these pseudogenes were found in inbred mice and M. spretus, some are species specific. This suggests that there have been active phases of pseudogene formation in Mus both before and after the separation of musculus and spretus. The human genome contains no pseudogenes; we assigned the human gene to chromosome 19, consistent with the location of mouse and human functional genes for MIF in a region of conserved linkage.

journal_name

Genomics

journal_title

Genomics

authors

Kozak CA,Adamson MC,Buckler CE,Segovia L,Paralkar V,Wistow G

doi

10.1006/geno.1995.1070

subject

Has Abstract

pub_date

1995-06-10 00:00:00

pages

405-11

issue

3

eissn

0888-7543

issn

1089-8646

pii

S0888-7543(85)71070-1

journal_volume

27

pub_type

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