Abstract:
:Nitric oxide (NO) is an important molecular messenger regulating the functions of a wide variety of cells and tissues. NO is synthesized from L-arginine by a variety of isoforms of the enzyme nitric oxide synthase (NOS). We have used Southern blotting analysis on DNAs obtained from a panel of human-rodent hybrid cell lines to map the gene encoding the inducible NOS (NOS2) to chromosome 17cen-17q11 and the gene encoding the endothelial form of NOS (NOS3) to chromosome 7. Fluorescence in situ hybridization using a NOS2 probe gave several signals in the 17p11-q11 pericentromeric region.
journal_name
Genomicsjournal_title
Genomicsauthors
Xu W,Charles IG,Moncada S,Gorman P,Sheer D,Liu L,Emson Pdoi
10.1006/geno.1994.1286subject
Has Abstractpub_date
1994-05-15 00:00:00pages
419-22issue
2eissn
0888-7543issn
1089-8646pii
S0888-7543(84)71286-9journal_volume
21pub_type
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