Abstract:
:We have isolated a human homologue (MEST) of the mouse mesoderm-specific transcript (Mest) gene that shares about 70% nucleotide sequence homology. Northern blot analysis showed that the MEST gene was expressed in all major fetal organs and tissues so far examined, i.e., amnion, brain, heart, lung, stomach, gut, adrenal, kidney, muscle, and liver, which does not contradict with mesoderm-specific expression. MEST was abundantly expressed in hydatidiform moles of androgenetic origin, whereas it was barely detectable in dermoid cysts of parthenogenetic origin. Thus, it seems likely that the MEST gene, mapped to 7q32 by fluorescence in situ hybridization, is maternally repressed as the mouse homologue.
journal_name
Genomicsjournal_title
Genomicsauthors
Nishita Y,Yoshida I,Sado T,Takagi Ndoi
10.1006/geno.1996.0502subject
Has Abstractpub_date
1996-09-15 00:00:00pages
539-42issue
3eissn
0888-7543issn
1089-8646pii
S0888-7543(96)90502-9journal_volume
36pub_type
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