Abstract:
:Seven-in-absentia (sina) is epistatic to all other known genes in the sevenless-ras signaling pathway, which mediates R7 photoreceptor formation in the Drosophila eye. The murine genome contains several closely related sina homologues (Siah1A-D, Siah2) that are also likely to participate in ras signaling. As part of a genetic and biochemical analysis of the mammalian Siah genes, we have used gene-specific probes to map the chromosomal positions of each family member. Here we report their chromosomal positions in relation to a number of known mouse mutations and also describe an analysis of the human Siah genes. By comparing the complexity of the Siah genes in these two mammalian species we have gained further insight into which members of this murine multigene family are likely to be functional.
journal_name
Genomicsjournal_title
Genomicsauthors
Holloway AJ,Della NG,Fletcher CF,Largespada DA,Copeland NG,Jenkins NA,Bowtell DDdoi
10.1006/geno.1997.4642subject
Has Abstractpub_date
1997-04-15 00:00:00pages
160-8issue
2eissn
0888-7543issn
1089-8646pii
S0888-7543(97)94642-5journal_volume
41pub_type
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