Chromosomal mapping of five highly conserved murine homologues of the Drosophila RING finger gene seven-in-absentia.

Abstract:

:Seven-in-absentia (sina) is epistatic to all other known genes in the sevenless-ras signaling pathway, which mediates R7 photoreceptor formation in the Drosophila eye. The murine genome contains several closely related sina homologues (Siah1A-D, Siah2) that are also likely to participate in ras signaling. As part of a genetic and biochemical analysis of the mammalian Siah genes, we have used gene-specific probes to map the chromosomal positions of each family member. Here we report their chromosomal positions in relation to a number of known mouse mutations and also describe an analysis of the human Siah genes. By comparing the complexity of the Siah genes in these two mammalian species we have gained further insight into which members of this murine multigene family are likely to be functional.

journal_name

Genomics

journal_title

Genomics

authors

Holloway AJ,Della NG,Fletcher CF,Largespada DA,Copeland NG,Jenkins NA,Bowtell DD

doi

10.1006/geno.1997.4642

subject

Has Abstract

pub_date

1997-04-15 00:00:00

pages

160-8

issue

2

eissn

0888-7543

issn

1089-8646

pii

S0888-7543(97)94642-5

journal_volume

41

pub_type

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