Abstract:
:The Tcp-1 gene is located in the t-complex region of mouse chromosome 17 and on the long arm of human chromosome 6. In the mouse, a related gene, Tcp-1x, is tightly linked to Tcp-1. It is shown here that two genes located 3' to the murine Tcp-1 and Tcp-1x genes code for proteins highly homologous to acetyl-CoA acetyltransferases. These genes (Acat-1 and Acat-2) are in the opposite orientation to the Tcp-1 genes, and transcription results in mRNA species that contain the last exon of Tcp-1 or Tcp-1x within the 3' untranslated region of the respective Acat mRNA. Both Acat genes appear to be transcribed in several mouse tissues. An ACAT gene also overlaps the TCP1 gene in humans, suggesting that this close linkage may have some functional significance.
journal_name
Genomicsjournal_title
Genomicsauthors
Ashworth Adoi
10.1006/geno.1993.1454subject
Has Abstractpub_date
1993-11-01 00:00:00pages
195-8issue
2eissn
0888-7543issn
1089-8646pii
S0888-7543(83)71454-0journal_volume
18pub_type
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