Abstract:
:TFE3, a member of the helix-loop-helix family of transcription factors, binds to the microE3 motif of the immunoglobulin heavy-chain enhancer and is expressed in many cell types. We have localized human TFE3 to the proximal short arm of the X chromosome using a somatic cell hybrid panel. A frequent RsaI RFLP detected by the TFE3 cDNA was found and used to confirm this location by linkage analysis in 20 pedigrees. Two-point and multipoint lod scores place TFE3 near markers in Xp11.22 with the most likely order DXS7-DXS255-TFE3-DXS146-DXS14.
journal_name
Genomicsjournal_title
Genomicsauthors
Henthorn PS,Stewart CC,Kadesch T,Puck JMdoi
10.1016/0888-7543(91)90145-5subject
Has Abstractpub_date
1991-10-01 00:00:00pages
374-8issue
2eissn
0888-7543issn
1089-8646pii
0888-7543(91)90145-5journal_volume
11pub_type
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