Abstract:
:Familial hypertrophic cardiomyopathy (HCM) is a primary myocardial disease with a prevalence of 1 in 500 in human beings. Causative mutations have been identified in several sarcomeric genes, including the cardiac myosin binding protein C (MYBPC3) gene. Heritable HCM also exists in a large-animal model, the cat, and we have previously reported a mutation in the MYBPC3 gene in the Maine coon breed. We now report a separate mutation in the MYBPC3 gene in ragdoll cats with HCM. The mutation changes a conserved arginine to tryptophan and appears to alter the protein structure. The ragdoll is not related to the Maine coon and the mutation identified is in a domain different from that of the previously identified feline mutation. The identification of two separate mutations within this gene in unrelated breeds suggests that these mutations occurred independently rather than being passed on from a common founder.
journal_name
Genomicsjournal_title
Genomicsauthors
Meurs KM,Norgard MM,Ederer MM,Hendrix KP,Kittleson MDdoi
10.1016/j.ygeno.2007.04.007subject
Has Abstractpub_date
2007-08-01 00:00:00pages
261-4issue
2eissn
0888-7543issn
1089-8646pii
S0888-7543(07)00096-1journal_volume
90pub_type
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