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Characterization of the polycystic kidney disease 2 gene promoter.

Abstract：

:The key regulatory elements for PKD2 transcription remain unclear. To identify these core elements, we characterized porcine PKD2 promoter with bioinformatics and molecular tools and found porcine PKD2 promoter bearing typical features of enriched CpG and less TATA. Further studies demonstrated that the core region was located in fragment -483 to +100. Subsequent biophysical binding assays and mutation experiments revealed that G4 motif and Sp1 are critical regulators for mediating the transcription of porcine PKD2. Moreover, the same regulatory pattern was reproduced in human PKD2 promoter region, indicating the critical role of G4 and Sp1 in regulating PKD2.

journal_name

Genomics

journal_title

Genomics

authors

Wang Q,Han G,Ye J,Gao X,Niu H,Zhao J,Chai Y,Li N,Yin H

doi

10.1016/j.ygeno.2014.08.006

subject

Has Abstract

pub_date

2014-12-01 00:00:00

pages

512-9

issue

6 Pt B

eissn

0888-7543

issn

1089-8646

pii

S0888-7543(14)00148-7

journal_volume

104

pub_type

杂志文章

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