Abstract:
:The intercellular adhesion molecules ICAM1 and ICAM2 are the cell-surface ligands for the lymphocyte function-associated antigen LFA-1 (CD11a/CD18) and are thought to mediate cell-cell adhesion interactions required by the immune system. However, differences in tissue distribution, inducibility of expression, and overall structure of the two ICAMs may point to their having distinct functional roles. We have used a panel of somatic cell hybrids and chromosome-mediated gene transfectants to establish the chromosomal location of the gene for ICAM2. Hybridization of an ICAM2 cDNA clone to Southern blots from this panel indicates that the human ICAM2 gene maps to chromosome 17 region q23-25.
journal_name
Genomicsjournal_title
Genomicsauthors
Sansom D,Borrow J,Solomon E,Trowsdale Jdoi
10.1016/0888-7543(91)90157-asubject
Has Abstractpub_date
1991-10-01 00:00:00pages
462-4issue
2eissn
0888-7543issn
1089-8646pii
0888-7543(91)90157-Ajournal_volume
11pub_type
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