Abstract:
:The nervous and immune systems share many functional and molecular similarities, including shared surface antigens, secretions of soluble factors, and cross-modulatory effects. We have identified previously a novel mRNA termed F5, which is expressed only in activated T lymphocytes and mature, postmitotic neurons. Tissue specificity and sequence conservation suggest an important function for F5 in T-lymphocyte proliferation and neuronal maturation. The F5 gene product is an evolutionarily conserved, cytoskeletal-associated phosphoprotein. A full-length mouse genomic clone has been isolated. The protein coding region of the F5 gene is approximately 16 kb in length and is composed of 13 coding exons. The gene encoding F5, termed I2rf5, was mapped using interspecies mouse crosses in close proximity to a number of genes associated with neuronal defects on distal chromosome 4.
journal_name
Genomicsjournal_title
Genomicsauthors
Autieri MV,Kozak CA,Cohen JA,Prystowsky MBdoi
10.1016/0888-7543(95)80137-bsubject
Has Abstractpub_date
1995-01-01 00:00:00pages
282-4issue
1eissn
0888-7543issn
1089-8646pii
0888-7543(95)80137-Bjournal_volume
25pub_type
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