Abstract:
:A mouse inositol polyphosphate 1-phosphatase (Inpp1) cDNA fragment (348 bp) was amplified by means of the polymerase chain reaction using a mouse cDNA library as template with primers designed from published human and bovine cDNA sequences. We isolated a 1623-bp full-length Inpp1 cDNA from a mouse brain cDNA library using this amplified cDNA fragment as probe. Amino acid sequences of mouse, human, and bovine inositol polyphosphate 1-phosphatase are highly conserved. Northern blot analysis shows a major transcript of 1.65-kb mRNA and several higher molecular weight mRNAs that are expressed in a variety of mouse tissues. Utilizing the Jackson Lab backcross DNA panel map service, we mapped Inpp1 to chromosome 1, 1.06 cM proximal to Ctla4.
journal_name
Genomicsjournal_title
Genomicsauthors
Okabe I,Nussbaum RLdoi
10.1006/geno.1995.0030subject
Has Abstractpub_date
1995-11-20 00:00:00pages
358-60issue
2eissn
0888-7543issn
1089-8646pii
S0888-7543(85)70030-4journal_volume
30pub_type
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