Abstract:
:The alpha 1 subunit genes encoding voltage-dependent Ca2+ channels are members of a gene family. We have used human brain cDNA probes to localize the neuronal isoform genes CACNL1A4 (alpha 1A), CACNL1A5 (alpha 1B), and CACNL1A6 (alpha 1E) to 19p13, 9q34, and 1q25-q31, respectively, using fluorescence in situ hybridization on human chromosomes. These genes are particularly interesting gene candidates in the pathogenesis of neuronal disorders. Although genetic disorders have been linked to loci 9q34 and 19p13, no genetic disease related to Ca2+ signaling defects has yet been linked to these loci.
journal_name
Genomicsjournal_title
Genomicsauthors
Diriong S,Lory P,Williams ME,Ellis SB,Harpold MM,Taviaux Sdoi
10.1006/geno.1995.1284subject
Has Abstractpub_date
1995-12-10 00:00:00pages
605-9issue
3eissn
0888-7543issn
1089-8646pii
S0888-7543(85)71284-0journal_volume
30pub_type
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