Abstract:
:Non-coding RNA (ncRNA) is a kind of RNA, produced by genomic transcription and does not encode protein, but can regulate the function of genes, thus widely regulating pathological and physiological processes. The dynamic balance of the reticular structure between them is needed to regulate the homeostasis, the abnormal regulation of one of them may lead to the occurrence of the disease. CircRNA is mainly involved in the evolution of CVD through sponge-like regulation of miRNAs, subsequently regulating miRNAs and their targets, mRNA functions. The role of circRNA-miRNA-mRNA axis in pathogenesis of cardiovascular diseases has been recently reported and highlighted. In this review, the emerging roles of circRNA-miRNA-mRNA axis in cardiovascular pathophysiology and regulation were discussed, with a novel focus on cardioprotective network activities of the circRNA.
journal_name
Genomicsjournal_title
Genomicsauthors
Su Q,Lv Xdoi
10.1016/j.ygeno.2019.10.006subject
Has Abstractpub_date
2020-03-01 00:00:00pages
1680-1685issue
2eissn
0888-7543issn
1089-8646pii
S0888-7543(19)30565-8journal_volume
112pub_type
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