Abstract:
:Premature ovarian failure (POF) is characterized by heterogeneous genetic causes such as chromosomal abnormalities and variants in causal genes. Recently, development of techniques made next generation sequencing (NGS) possible to detect genome wide variants including chromosomal abnormalities. Among 37 Korean POF patients, XY karyotype with distal part deletions of Y chromosome, Yp11.32-31 and Yp12 end part, was observed in two patients through NGS. Six deleterious variants in POF genes were also detected which might explain the pathogenesis of POF with abnormalities in the sex chromosomes. Additionally, the two POF patients had no mutation in SRY but three non-synonymous variants were detected in genes regarding sex reversal. These findings suggest candidate causes of POF and sex reversal and show the propriety of NGS to approach the heterogeneous pathogenesis of POF.
journal_name
Genomicsjournal_title
Genomicsauthors
Lee Y,Kim C,Park Y,Pyun JA,Kwack Kdoi
10.1016/j.ygeno.2016.10.006subject
Has Abstractpub_date
2016-12-01 00:00:00pages
209-215issue
5-6eissn
0888-7543issn
1089-8646pii
S0888-7543(16)30098-2journal_volume
108pub_type
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