Abstract:
:The DBA/2J inbred strain of mice is used extensively in hearing research, yet little is known about the genetic basis for its early onset, progressive hearing loss. To map underlying genetic factors we analyzed recombinant inbred strains and linkage backcrosses. Analysis of 213 mice from 31 BXD recombinant inbred strains detected linkage of auditory brain-stem response thresholds with a locus on distal chromosome 11, which we designate ahl8. Analysis of 225 N2 mice from a backcross of (C57BL/6JxDBA/2J) F1 hybrids to DBA/2J mice confirmed this linkage (LOD>50) and refined the ahl8 candidate gene interval. Analysis of 214 mice from a backcross of (B6.CAST-Cdh23 Ahl+ xDBA/2J) F1 hybrids to DBA/2J mice demonstrated a genetic interaction of Cdh23 with ahl8. We conclude that ahl8 is a major contributor to the hearing loss of DBA/2J mice and that its effects are dependent on the predisposing Cdh23 ahl genotype of this strain.
journal_name
Genomicsjournal_title
Genomicsauthors
Johnson KR,Longo-Guess C,Gagnon LH,Yu H,Zheng QYdoi
10.1016/j.ygeno.2008.06.007subject
Has Abstractpub_date
2008-10-01 00:00:00pages
219-25issue
4eissn
0888-7543issn
1089-8646pii
S0888-7543(08)00145-6journal_volume
92pub_type
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