The mouse biliary glycoprotein gene (Bgp): partial nucleotide sequence, expression, and chromosomal assignment.


:Transcripts related to the human carcinoembryonic antigen were found in mRNA isolated from both dimethylbenzanthracene-induced and mouse mammary tumor virus-induced mammary tumors. A cDNA library was prepared from a dimethylbenzanthracene-induced tumor, and a clone was isolated by hybridization with a human carcinoembryonic antigen cDNA probe. Its sequence, when compared to those of members of the human carcinoembryonic antigen gene family, was most homologous to the sequence of the human biliary glycoprotein (BGP) gene. Thus, this clone appears to encode a portion of the mouse biliary glycoprotein gene. Southern blot analysis of EcoRI-digested mouse cellular DNA with this probe detected four restriction fragments, all of which appear to be located on mouse chromosome 7, Northern blot analysis using the mouse probe demonstrated that related mRNA species were expressed in some normal adult mouse tissues.






Robbins J,Robbins PF,Kozak CA,Callahan R




Has Abstract


1991-07-01 00:00:00














  • The complete sequences of the galago and rabbit beta-globin locus control regions: extended sequence and functional conservation outside the cores of DNase hypersensitive sites.

    abstract::The locus control region (LCR) of mammalian beta-globin genes covers at least 17 kb at the 5' end of the gene cluster and has been implicated in chromatin domain opening, enhancement, and insulation from neighboring sequences. Functional dissection of the LCR has defined the minimal cores for four of the five major DN...


    pub_type: 杂志文章


    authors: Slightom JL,Bock JH,Tagle DA,Gumucio DL,Goodman M,Stojanovic N,Jackson J,Miller W,Hardison R

    更新日期:1997-01-01 00:00:00

  • Structural organization of the human prostaglandin EP3 receptor subtype gene (PTGER3).

    abstract::Prostaglandin EP3 receptor subtype is a seven-membrane-spanning protein with multiple C-terminal tails generated by alternative mRNA splicing. We report here the structural organization of the human EP3 gene (PTGER3). The human EP3 gene spanned more than 80 kb and was composed of 10 exons separated by nine introns. Ex...


    pub_type: 杂志文章


    authors: Kotani M,Tanaka I,Ogawa Y,Usui T,Tamura N,Mori K,Narumiya S,Yoshimi T,Nakao K

    更新日期:1997-03-15 00:00:00

  • Construction and characterization of a bovine bacterial artificial chromosome library.

    abstract::A bacterial artificial chromosome (BAC) library has been constructed for use in bovine genome mapping using constructed for use in bovine genome mapping using the pBeloBAC11 vector. Currently, the library consists of 23,040 clones, which achieves a 70% probability (P=0.70) of the library containing a specific unique D...


    pub_type: 杂志文章


    authors: Cai L,Taylor JF,Wing RA,Gallagher DS,Woo SS,Davis SK

    更新日期:1995-09-20 00:00:00

  • Chromosome localization and genomic structure of the KiSS-1 metastasis suppressor gene (KISS1).

    abstract::The identification and sequence of KiSS-1 (HGMW-approved symbol, KISS1), a human malignant melanoma metastasis-suppressor gene, was recently published. In this report, we present a corrected genomic sequence, genomic structure, and refined chromosomal location for KiSS-1. The genomic organization of the sequence revea...


    pub_type: 杂志文章


    authors: West A,Vojta PJ,Welch DR,Weissman BE

    更新日期:1998-11-15 00:00:00

  • Identification of putative transmembrane receptor sequences homologous to the calcium-sensing G-protein-coupled receptor.

    abstract::The sensing of extracellular calcium is a general paradigm for regulating diverse cellular functions in many tissues. A calcium-sensing receptor (Casr) belonging to the metabotropic glutamate family of G-protein-coupled receptors (GPCR) that transduces the effects of extracellular calcium in the parathyroid gland as w...


    pub_type: 杂志文章


    authors: Hinson TK,Damodaran TV,Chen J,Zhang X,Qumsiyeh MB,Seldin MF,Quarles LD

    更新日期:1997-10-15 00:00:00

  • Wdr12, a mouse gene encoding a novel WD-Repeat Protein with a notchless-like amino-terminal domain.

    abstract::The WD-repeat protein family consists of a large group of structurally related yet functionally diverse proteins found predominantly in eukaryotic cells. These factors contain several (4-16) copies of a recognizable amino-acid sequence motif (the WD unit) thought to be organized into a "propeller-like" structure invol...


    pub_type: 杂志文章


    authors: Nal B,Mohr E,Silva MI,Tagett R,Navarro C,Carroll P,Depetris D,Verthuy C,Jordan BR,Ferrier P

    更新日期:2002-01-01 00:00:00

  • Comparative genomics study for identification of drug and vaccine targets in Vibrio cholerae: MurA ligase as a case study.

    abstract::A systematic workflow consisting of comparative genomics, metabolic pathways analysis and additional drug prioritization parameters identified 264 proteins of Vibrio cholerae which were predicted to be absent in Homo sapiens. Among these, 40 proteins were identified as essential proteins that could serve as potential ...


    pub_type: 杂志文章


    authors: Chawley P,Samal HB,Prava J,Suar M,Mahapatra RK

    更新日期:2014-01-01 00:00:00

  • Conserved interactions of a compact highly active enhancer/promoter upstream of the rhodopsin kinase (GRK1) gene.

    abstract::Rhodopsin kinase (RK) is a conserved component of the light adaptation and recovery pathways shared among rod and cone photoreceptors of a variety of species. To gain insight into transcriptional mechanisms driving RK and potentially other genes of similar spatial profile, the components and the interactions of the hi...


    pub_type: 杂志文章


    authors: Young JE,Kasperek EM,Vogt TM,Lis A,Khani SC

    更新日期:2007-08-01 00:00:00

  • Prp (proline-rich protein) genes linked to markers Es-12 (esterase-12), Ea-10 (erythrocyte alloantigen), and loci on distal mouse chromosome 6.

    abstract::The closely linked proline-rich protein (Prp) genes, coding for abundant salivary proteins, are located on distal mouse chromosome 6. They are part of a conserved linkage group that is represented on human chromosome 12p. Two other markers, Ea-10 and Es-12, that were previously unassigned to a chromosome are closely l...


    pub_type: 杂志文章


    authors: Azen EA,Davisson MT,Cherry M,Taylor BA

    更新日期:1989-10-01 00:00:00

  • Haplotype analysis of the apolipoprotein gene cluster on human chromosome 11.

    abstract::Members of the apolipoprotein gene cluster (APOA1/C3/A4/A5) on human chromosome 11q23 play an important role in lipid metabolism. Polymorphisms in both APOA5 and APOC3 are strongly associated with plasma triglyceride concentrations. The close genomic locations of these two genes as well as their functional similarity ...


    pub_type: 杂志文章


    authors: Olivier M,Wang X,Cole R,Gau B,Kim J,Rubin EM,Pennacchio LA

    更新日期:2004-05-01 00:00:00

  • Transcription mapping in a medulloblastoma breakpoint interval and Smith-Magenis syndrome candidate region: identification of 53 transcriptional units and new candidate genes.

    abstract::The chromosomal band 17p11.2 is associated with a number of neurological disorders and malignant diseases. This region is also characterized by the presence of complex repeat elements that are probably responsible for the frequent occurrence of interstitial deletions, duplications, and isochromosome formation. In the ...


    pub_type: 杂志文章


    authors: Seranski P,Heiss NS,Dhorne-Pollet S,Radelof U,Korn B,Hennig S,Backes E,Schmidt S,Wiemann S,Schwarz CE,Lehrach H,Poustka A

    更新日期:1999-02-15 00:00:00

  • Mapping of the human CENP-B gene to chromosome 20 and the CENP-C gene to chromosome 12 by a rapid cycle DNA amplification procedure.

    abstract::By optimizing the primer-annealing temperature in a rapid air cycling procedure, two human DNA sequences encoding centromere proteins B and C (CENP-B and CENP-C) were specifically amplified without any detectable amplification of highly homologous rodent DNA sequences. Using a panel of rodent/human hybrid DNA, the gen...


    pub_type: 杂志文章


    authors: Sugimoto K,Yata H,Himeno M

    更新日期:1993-07-01 00:00:00

  • MetaCAA: A clustering-aided methodology for efficient assembly of metagenomic datasets.

    abstract::A key challenge in analyzing metagenomics data pertains to assembly of sequenced DNA fragments (i.e. reads) originating from various microbes in a given environmental sample. Several existing methodologies can assemble reads originating from a single genome. However, these methodologies cannot be applied for efficient...


    pub_type: 杂志文章


    authors: Reddy RM,Mohammed MH,Mande SS

    更新日期:2014-02-01 00:00:00

  • Mapping of 228 ESTs and 26 genes into an integrated physical and genetic map of human chromosome 17.

    abstract::We have integrated genetic and physical mapping data for chromosome 17 subdivided into 26 bins, by using a panel of chromosome 17 deletion somatic cell hybrids. One hundred four short tandem repeat and STS markers have been localized into these bins and have enabled the ordering of 288 ESTs and 26 genes, including 142...


    pub_type: 杂志文章


    authors: Plummer SJ,Simmons JA,Adams L,Casey G

    更新日期:1997-10-01 00:00:00

  • Structure, chromosomal locus, and promoter of mouse Hes2 gene, a homologue of Drosophila hairy and Enhancer of split.

    abstract::Hes2 encodes a mammalian basic helix-loop-helix transcriptional repressor homologous to the products of Drosophila hairy and Enhancer of split. Here, we isolated and characterized the mouse Hes2 gene. This gene consists of four exons, and all the introns are located within the protein-coding region at positions homolo...


    pub_type: 杂志文章


    authors: Nishimura M,Isaka F,Ishibashi M,Tomita K,Tsuda H,Nakanishi S,Kageyama R

    更新日期:1998-04-01 00:00:00

  • Chromosomal distribution of the human cardiovascular transcriptome.

    abstract::On the basis of previous observations in chromosomes 21 and 22, we hypothesize that there is a tissue-specific organization of cardiovascular gene transcripts in the human genome. To examine the distribution of heart-derived transcripts, we assigned a nonredundant set of 4628 fetal and 3574 adult known and uncharacter...


    pub_type: 杂志文章


    authors: Barrans JD,Ip J,Lam CW,Hwang IL,Dzau VJ,Liew CC

    更新日期:2003-05-01 00:00:00

  • Human uroporphyrinogen-III synthase: genomic organization, alternative promoters, and erythroid-specific expression.

    abstract::Uroporphyrinogen-III (URO) synthase is the heme biosynthetic enzyme defective in congenital erythropoietic porphyria. The approximately 34-kb human URO-synthase gene (UROS) was isolated, and its organization and tissue-specific expression were determined. The gene had two promoters that generated housekeeping and eryt...


    pub_type: 杂志文章


    authors: Aizencang G,Solis C,Bishop DF,Warner C,Desnick RJ

    更新日期:2000-12-01 00:00:00

  • Genome-wide identification and comprehensive analysis of Excretory/Secretory proteins in nematodes provide potential drug targets for parasite control.

    abstract::Nematodes are responsible for causing severe diseases in plants, humans and other animals. Infection is associated with the release of Excretory/Secretory (ES) proteins into host cytoplasm and interference with the host immune system which make them attractive targets for therapeutic use. The identification of ES prot...


    pub_type: 杂志文章


    authors: Gahoi S,Singh S,Gautam B

    更新日期:2019-05-01 00:00:00

  • Polymorphisms in matricellular SPP1 and SPARC contribute to susceptibility to papillary thyroid cancer.

    abstract::There is a compelling need to identify novel genetic variants for papillary thyroid cancer (PTC) susceptibility. The Cancer Genome Atlas (TCGA) data showed associations between SPP1 and SPARC mRNA overexpression and aggressive behaviors of PTC, which prompted us to assess potential associations between genetic variant...


    pub_type: 杂志文章


    authors: Su X,Xu BH,Zhou DL,Ye ZL,He HC,Yang XH,Zhang X,Liu Q,Ma JJ,Shao Q,Yang AK,He CY

    更新日期:2020-11-01 00:00:00

  • Characterization of a human gene encoding nucleosomal binding protein NSBP1.

    abstract::We characterize the cDNA and genomic structure of NSBP1, and demonstrate that it is a nuclear protein and the homologue of mouse Nsbp1, which is known to encode a nucleosomal binding and transcriptional activating protein related to the HMG-14/-17 chromosomal proteins. The encoded NSBP1 protein has 86% amino acid simi...


    pub_type: 杂志文章


    authors: King LM,Francomano CA

    更新日期:2001-01-15 00:00:00

  • Precise mapping of the brain alpha 2-adrenergic receptor gene within chromosome 4p16.

    abstract::The gene encoding the brain alpha 2-adrenergic receptor (ADRA2C) is located on human chromosome 4. It has been circumstantially associated with a number of human disorders, including Parkinson disease, panic disorders, and Huntington disease (HD). Using somatic cell hybrids, we localized the gene to chromosome 4p16 di...


    pub_type: 杂志文章


    authors: Riess O,Thies U,Siedlaczck I,Potisek S,Graham R,Theilmann J,Grimm T,Epplen JT,Hayden MR

    更新日期:1994-01-15 00:00:00

  • Genomic mapping by anchoring random clones: a mathematical analysis.

    abstract::A complete physical map of the DNA of an organism, consisting of overlapping clones spanning the genome, is an extremely useful tool for genomic analysis. Various methods for the construction of such physical maps are available. One approach is to assemble the physical map by "fingerprinting" a large number of random ...


    pub_type: 杂志文章


    authors: Arratia R,Lander ES,Tavaré S,Waterman MS

    更新日期:1991-12-01 00:00:00

  • A novel human Mcm protein: homology to the yeast replication protein Mis5 and chromosomal location.

    abstract::Mcm proteins perform functions related to the regulation of eukaryotic genome replication. Previous work has shown that human cells contain at least five different Mcm proteins. We report now the amino acid sequence of an additional human Mcm protein, p105Mcm, and show that it is homologous to the Schizosaccharomyces ...


    pub_type: 杂志文章


    authors: Holthoff HP,Hameister H,Knippers R

    更新日期:1996-10-01 00:00:00

  • Pathogenic 12-kb copy-neutral inversion in syndromic intellectual disability identified by high-fidelity long-read sequencing.

    abstract::We report monozygotic twin girls with syndromic intellectual disability who underwent exome sequencing but with negative pathogenic variants. To search for variants that are unrecognized by exome sequencing, high-fidelity long-read genome sequencing (HiFi LR-GS) was applied. A 12-kb copy-neutral inversion was precisel...


    pub_type: 杂志文章


    authors: Mizuguchi T,Okamoto N,Yanagihara K,Miyatake S,Uchiyama Y,Tsuchida N,Hamanaka K,Fujita A,Miyake N,Matsumoto N

    更新日期:2020-11-04 00:00:00

  • Chromosomal localization of a cytochrome b5 gene to human chromosome 18 and a cytochrome b5 pseudogene to the X chromosome.

    abstract::We have isolated cDNA clones that code for human cytochrome b5. Owing to the high degree of evolutionary conservation of cytochrome b5 sequences and the existence of human and rodent cytochrome b5 processed pseudogenes, we were unable to map unambiguously the chromosomal localization of the human gene(s) by Southern b...


    pub_type: 杂志文章


    authors: Shephard EA,Povey S,Spurr NK,Phillips IR

    更新日期:1991-10-01 00:00:00

  • Complete structural organization of the human alpha 1 (V) collagen gene (COL5A1): divergence from the conserved organization of other characterized fibrillar collagen genes.

    abstract::Genes that encode the vertebrate fibrillar collagen types I-III have previously been shown to share a highly conserved intron/exon organization, thought to reflect common ancestry and evolutionary pressures at the protein level. We report here the complete intron/exon organization of COL5A1, the human gene that encode...


    pub_type: 杂志文章


    authors: Takahara K,Hoffman GG,Greenspan DS

    更新日期:1995-10-10 00:00:00

  • The Mass1frings mutation underlies early onset hearing impairment in BUB/BnJ mice, a model for the auditory pathology of Usher syndrome IIC.

    abstract::The human ortholog of the gene responsible for audiogenic seizure susceptibility in Frings and BUB/BnJ mice (mouse gene symbol Mass1) recently was shown to underlie Usher syndrome type IIC (USH2C). Here we report that the Mass1frings mutation is responsible for the early onset hearing impairment of BUB/BnJ mice. We fo...


    pub_type: 杂志文章


    authors: Johnson KR,Zheng QY,Weston MD,Ptacek LJ,Noben-Trauth K

    更新日期:2005-05-01 00:00:00

  • 1.5-Mb YAC contig in Xq28 formatted with sequence-tagged sites and including a region unstable in the clones.

    abstract::A contig of 20 yeast artificial clones (YACs) has been assembled across 1.5 Mb of Xq28 and formatted with nine previously reported probes and nine STSs developed from the sequence of probes and end fragments of YACs. YAC end fragments were obtained by subcloning, Alu-vector PCR, or primer-ligation PCR methods. Eightee...


    pub_type: 杂志文章


    authors: Palmieri G,Romano G,Casamassimi A,D'Urso M,Little RD,Abidi FE,Schlessinger D,Lagerström M,Malmgren H,Steen-Bondeson ML

    更新日期:1993-06-01 00:00:00

  • Transcriptional regulation in eukaryotic ribosomal protein genes.

    abstract::Understanding ribosomal protein gene regulation provides a good avenue for understanding gene regulatory networks. Even after 5 decades of research on ribosomal protein gene regulation, little is known about how higher eukaryotic ribosomal protein genes are coordinately regulated at the transcriptional level. However,...


    pub_type: 杂志文章,评审


    authors: Hu H,Li X

    更新日期:2007-10-01 00:00:00

  • Sequencing, transcript identification, and quantitative gene expression profiling in the breast cancer loss of heterozygosity region 16q24.3 reveal three potential tumor-suppressor genes.

    abstract::Loss of heterozygosity (LOH) of chromosome 16q24.3 is a common genetic alteration observed in invasive ductal and lobular breast carcinomas. We constructed a physical map and generated genomic DNA sequence data spanning 2.4 Mb in this region. Detailed in silico and in vitro analyses of the genomic sequence data enable...


    pub_type: 杂志文章


    authors: Powell JA,Gardner AE,Bais AJ,Hinze SJ,Baker E,Whitmore S,Crawford J,Kochetkova M,Spendlove HE,Doggett NA,Sutherland GR,Callen DF,Kremmidiotis G

    更新日期:2002-09-01 00:00:00