Abstract:
:A relatively abundant component of the polymorphonuclear leukocyte granulocytes has been recently isolated and called defensin. Defensins have antimicrobial activity against gram-positive and gram-negative bacteria and enveloped viruses. A cDNA insert for defensin HNP-1 (DEF1) has been used to map the gene(s) to human chromosome 8p23 using a mouse/human somatic cell hybrid panel and in situ hybridization to normal human metaphase chromosomes. Because of the similarity of HNP-1 defensin to other defensins, it is likely that two of these genes map to this region.
journal_name
Genomicsjournal_title
Genomicsauthors
Sparkes RS,Kronenberg M,Heinzmann C,Daher KA,Klisak I,Ganz T,Mohandas Tdoi
10.1016/0888-7543(89)90052-9subject
Has Abstractpub_date
1989-08-01 00:00:00pages
240-4issue
2eissn
0888-7543issn
1089-8646pii
0888-7543(89)90052-9journal_volume
5pub_type
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