Abstract:
:We have isolated and characterized genomic clones containing the mouse myelin/oligodendrocyte glycoprotein (MOG) gene. It spans a region of 12.5 kb and consists of eight exons. Its exon-intron structure differs from that of classical MHC-class I genes, with which it is linked in the mouse genome. Nucleotide sequencing of the 5' flanking region reveals that it contains several putative protein-binding sites, some of them in common with other myelin gene promoters. One intragenic polymorphism has been identified: it consists of a GA repeat, defining at least three alleles in mouse inbred strains, and is easily detectable using the polymerase chain reaction method.
journal_name
Genomicsjournal_title
Genomicsauthors
Daubas P,Pham-Dinh D,Dautigny Adoi
10.1006/geno.1994.1456subject
Has Abstractpub_date
1994-09-01 00:00:00pages
36-41issue
1eissn
0888-7543issn
1089-8646pii
S0888-7543(84)71456-Xjournal_volume
23pub_type
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