Abstract:
:A MspI polymorphism was detected in the beta-glucocerebrosidase gene in 10 Swedish families affected by type III Gaucher's disease. The sizes of the polymorphic fragments were 1.70 and 1.75 kb and the disease was found to segregate with the 1.70-kb fragment in 32 meioses. Only the 1.75-kb fragment was detected in families with no history of Gaucher's disease. The results indicate that the mutation causing type III Gaucher's disease has occurred once within the Swedish population. The polymorphism is useful for carrier detection since biochemical tests sometimes give inconclusive results.
journal_name
Genomicsjournal_title
Genomicsauthors
Dahl N,Erikson A,Hammarström-Heeroma K,Pettersson Udoi
10.1016/0888-7543(88)90118-8subject
Has Abstractpub_date
1988-11-01 00:00:00pages
296-8issue
4eissn
0888-7543issn
1089-8646journal_volume
3pub_type
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