Abstract:
:Among its known functions, tumor suppressor gene p53 serves as a transcriptional regulator and mediates various signals through activation of downstream genes. We recently identified a novel gene, GML (glycosylphosphatidylinositol (GPI)-anchored molecule-like protein), whose expression is specifically induced by wildtype p53. To characterize the GML gene further, we determined 35.8 kb of DNA sequence that included a consensus binding sequence for p53 and the entire GML gene. The GML gene consists of four exons; and the p53-binding sequence is present in the 5'-flanking region. In genomic organization this gene resembles genes encoding murine Ly-6 glycoproteins, a human homologue of the Ly-6 family called RIG-E, and CD59; products of these genes, known as GPI-anchored proteins, are variously involved in signal transduction, cell-cell adhesion, and cell-matrix attachment. FISH analysis revealed that the GML gene is located on human chromosome 8q24.3. Genes encoding at least two other GPI-anchored molecules, E48 and RIG-E, are also located in this region.
journal_name
Genomicsjournal_title
Genomicsauthors
Kimura Y,Furuhata T,Urano T,Hirata K,Nakamura Y,Tokino Tdoi
10.1006/geno.1997.4680subject
Has Abstractpub_date
1997-05-01 00:00:00pages
477-80issue
3eissn
0888-7543issn
1089-8646pii
S0888-7543(97)94680-2journal_volume
41pub_type
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