Abstract:
:Inducible costimulatory receptor (ICOS) is one recently identified member of the CD28 family of costimulatory molecules. Evidence suggests ICOS functions as a critical immune regulator and, to evaluate these effects, we employed the canine model system that has been used to develop strategies currently in clinical use for hematopoietic stem cell transplantation. To investigate the effects of blocking the ICOS pathway in the canine hematopoietic cell transplantation model, we tested existing murine and human reagents and cloned the full length of the open reading frame of canine ICOS cDNA to allow the development of reagents specific for the canine ICOS. Canine ICOS contains a major open reading frame of 624 nucleotides, encoding a protein of 208 amino acids, and localizes to chromosome 37. Canine ICOS shares 79% sequence identity with human ICOS, 70% with mouse, and 69% with rat. Canine ICOS expression is limited to stimulated PBMC.
journal_name
Genomicsjournal_title
Genomicsauthors
Lee JH,Joo YD,Yim D,Lee R,Ostrander EA,Loretz C,Little MT,Storb R,Kuhr CSdoi
10.1016/j.ygeno.2004.06.009subject
Has Abstractpub_date
2004-10-01 00:00:00pages
730-6issue
4eissn
0888-7543issn
1089-8646pii
S0888-7543(04)00170-3journal_volume
84pub_type
杂志文章相关文献
GENOMICS文献大全abstract::Most members of the large family of rhodopsin-like G-protein-coupled receptors possess an evolutionarily conserved Asp-Arg-Tyr (DRY) motif in the C-terminal region of the third transmembrane domain. Mutations of residues within this motif usually abolish receptor function and, when they occur naturally, can even cause...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2006.02.009
更新日期:2006-06-01 00:00:00
abstract::We report the mapping of the human gene MPB1 (c-myc promoter binding protein), a recently identified gene regulatory protein. MPB1 binds to the c-myc P2 promoter and exerts a negative regulatory role on c-myc transcription. Since exogenous expression from transfection of the MPB1 gene suppresses the tumorigenic proper...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1996.4499
更新日期:1997-02-01 00:00:00
abstract::The rat diabetes susceptibility gene, Lyp or Lymphopenia, has been localized to RNO4. Proximal to Lyp are the genes caspase-2 (Casp2) and pancreatic trypsin 1 (Prss1), while neuropeptide Y (Npy) is the closest distally positioned gene. In human, the three genes are syntenic on HSA7, but they are not on a conserved seg...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.2000.6130
更新日期:2000-04-01 00:00:00
abstract::The association of the HLA class III region with many diseases motivates the investigation of unidentified genes in the 30-kb segment between complement component genes Bf and C4. RD, which codes for a putative RNA binding protein, is 205 bp downstream of Bf. SKI2W (HGMW-approved symbol SKIV2L), a DEVH-box gene probab...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1998.5499
更新日期:1998-11-01 00:00:00
abstract::The human MAS proto-oncogene is situated at 6q25.3-q26, a region that is homologous to mouse chromosome 17 where two parentally imprinted genes (Mas and Igf2r) have previously been identified. We investigated the imprinting status of MAS in adult lesions to establish the imprinting status of this gene in humans, as ce...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1997.5063
更新日期:1997-12-15 00:00:00
abstract::Hematopoietic cell phosphatase (Hcph) was identified by amplification of conserved protein tyrosine phosphatase sequences from a myeloid cell line and is predominantly expressed in hematopoietic cells. Hcph is unique in containing two, tandemly repeated, src-homology 2 domains in the amino terminal region of the phosp...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/s0888-7543(05)80189-2
更新日期:1992-11-01 00:00:00
abstract::The desmogleins, together with the desmocollins, both members of the cadherin superfamily, are the adhesive proteins of the desmosome type of cell junction, characteristically found in epithelial cells. Three different human desmoglein isoforms are encoded by separate genes (DSG1, DSG2, and DSG3) located on chromosome...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(95)80067-v
更新日期:1995-01-20 00:00:00
abstract::We describe the construction of a high-resolution radiation hybrid (RH) map of the domestic cat genome, which includes 2662 markers, translating to an estimated average intermarker distance of 939 kilobases (kb). Targeted marker selection utilized the recent feline 1.9x genome assembly, concentrating on regions of low...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2008.09.010
更新日期:2009-04-01 00:00:00
abstract::Recent studies on the molecular mechanisms controlling the mammalian cell cycle have disclosed a large family of cdc2-related serine/threonine kinases. Among this gene family, the PCTAIRE protein kinases comprise a distinct subfamily of unknown cellular function. To analyze the genomic structure and chromosomal locati...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1994.1245
更新日期:1994-05-01 00:00:00
abstract::Pigeonpea is the main protein source for more than one billion people, and it shows a strong adaptation to biotic stress and abiotic stress. Gene duplication is a fundamental process in genome evolution. Although the draft sequence of the pigeonpea genome has been available since 2011, further analysis of tandem dupli...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2020.10.003
更新日期:2020-10-11 00:00:00
abstract::Autosomal dominant hereditary spastic paraplegia (AD-HSP) is a genetically heterogeneous disorder characterized by progressive spasticity of the lower limbs. A major locus (SPG4) causing AD-HSP in about 40% of the families was mapped to chromosome 2p. The analysis of six SPG4-linked AD-HSP families using the RED proce...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1999.5932
更新日期:1999-09-15 00:00:00
abstract::DNA hybridization was used to isolate a 2.04-kb cDNA encoding carboxyl ester lipase (CEL) from a mouse lactating mammary gland, lambda gt10 cDNA library. The cDNA sequence translated into a protein of 599 amino acids, including 20 amino acids of a putative signal peptide. Comparison of the deduced amino acid sequence ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1995.1221
更新日期:1995-09-01 00:00:00
abstract::The puffer fish, Fugu rubripes (Fugu), has been proposed as a model vertebrate genome. We have characterized two putative G-protein-coupled receptor encoding genes, FCB1A and FCB1B, obtained by degenerate PCR and low-stringency hybridization of a Fugu genomic library. These two genes show high homology to the human ca...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1996.0406
更新日期:1996-08-01 00:00:00
abstract::In this investigation, whole-genome identification and functional characterization of the cotton dehydrin genes was carried out. A total of 16, 7, and 7 dehydrin proteins were identified in G. hirsutum, G. arboreum and G. raimondii, respectively. Through RNA sequence data and RT-qPCR validation, Gh_A05G1554 (GhDHN_03)...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2019.11.003
更新日期:2020-03-01 00:00:00
abstract::Ultraconservation has been variously defined to describe sequences that have remained identical or nearly so over long periods of evolution to a degree that is higher than expected for sequences under typical constraints associated with protein-coding sequences, splice sites, or transcription factor binding sites. Mos...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2009.07.005
更新日期:2009-11-01 00:00:00
abstract::We report a comparative map of canine chromosome 1 (CFA1) incorporating single nucleotide polymorphisms (SNPs) and insertion/deletion (indel) polymorphisms, developed by using cross-species primers, radiation hybrid analysis, and pool-and-sequence identification of genetic variations. Fifty-five genes were chosen with...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2004.04.001
更新日期:2004-08-01 00:00:00
abstract::FAT, a new member of the human cadherin super-family, has been isolated from the T-leukemia cell line J6. The predicted protein closely resembles the Drosophila tumor suppressor fat, which is essential for controlling cell proliferation during Drosophila development. The gene has the potential to encode a large transm...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1995.9884
更新日期:1995-11-20 00:00:00
abstract::A cosmid library has been constructed with DNA isolated from a mouse/human hybrid cell line designated A15, which was previously characterized and shown to retain chromosome 15 as the only human material. The library was generated and stored as 34 independent pools of primary colonies at 8-10,000 colonies per pool. Sc...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1996.4517
更新日期:1997-02-15 00:00:00
abstract::Biologic effects of androgen on target cells are mediated in part by transcriptional regulation of androgen-regulated genes (ARGs) by androgen receptor. Using serial analysis of gene expression (SAGE), we have identified a comprehensive repertoire of ARGs in LNCaP cells. One of the SAGE-derived tags exhibiting homolog...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.2000.6214
更新日期:2000-06-15 00:00:00
abstract::TR4 is a new member of the nuclear hormone receptor family. This receptor is highly conserved in rat and human, but an in-frame insertion of 19 amino acid residues in the amino-terminal (A/B) region was found in the human homolog, which we refer to as hTR4alpha1. By reverse transcription-PCR (RT-PCR) we have identifie...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1996.0368
更新日期:1996-07-15 00:00:00
abstract::The human gene encoding the muscle-specific beta-enolase has been isolated. The beta-enolase gene was mapped to chromosome 17 by analysis of a panel of rodent-human somatic cell hybrids. The gene was further localized to the short arm and tentatively to the region 17pter-p11 by analysis of cell hybrids and transfectan...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(90)90467-9
更新日期:1990-01-01 00:00:00
abstract::Eight genes located on the short arm of the human X chromosome (MAOA, SYN1, OAT, OTC, CYBB, DMD, ZFX, POLA) have been mapped in several marsupial species by cell hybrid analysis and/or in situ hybridization using probes derived from human cDNA. Seven appear to be autosomal in all marsupial species examined. The eighth...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(91)90141-z
更新日期:1991-10-01 00:00:00
abstract::The human homologs of the mouse homeo box-containing genes, En-1 and En-2, which show homology to the Drosophila engrailed gene, have been isolated. The human EN1 gene was mapped to chromosome 2 by analysis of mouse-human somatic cell hybrids. The human EN2 gene was localized to chromosome 7, 7q32-7qter, by analysis o...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(89)90301-7
更新日期:1989-02-01 00:00:00
abstract:UNLABELLED:Next-generation sequencing data can be mapped to a reference genome to identify single-nucleotide polymorphisms/variations (SNPs/SNVs; called SNPs hereafter). In theory, SNPs can be compared across several samples and the differences can be used to create phylogenetic trees depicting relatedness among the sa...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2014.06.001
更新日期:2014-07-01 00:00:00
abstract::Full-length coding sequences of two novel human cadherin cDNAs were obtained by sequence analysis of several EST clones and 5' and 3' rapid amplification of cDNA ends (RACE) products. Exons for a third cDNA sequence were identified in a public-domain human genomic sequence, and the coding sequence was completed by 3' ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.2000.6305
更新日期:2000-09-15 00:00:00
abstract::Understanding patterns of linkage disequilibrium (LD) across genomes may facilitate association mapping studies to localize genetic variants influencing complex diseases, a recognition that led to the International Haplotype Mapping Project (HapMap). Divergent patterns of haplotype frequency and LD across global popul...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2006.03.003
更新日期:2006-11-01 00:00:00
abstract::Ten genes, located on the long arm of the human X chromosome, were mapped in several marsupial species by somatic cell analysis and in situ hybridization. All were located on the X chromosome in each species. We conclude that the long arm of the human X chromosome represents a highly conserved region that formed part ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(91)90352-f
更新日期:1991-04-01 00:00:00
abstract::The search for the gene for choroideremia (MIM 30310), a rare retinal dystrophy, has been of great interest due to the existence of several choroideremia patients with well-defined structural chromosome aberrations, thus providing the basis for a reverse genetics approach to the isolation of this disease gene. This re...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(90)90494-f
更新日期:1990-04-01 00:00:00
abstract::The chromosomal abnormality represented by an isodicentric X chromosome [idic(X)(q13)] is associated with a subset of acute myeloid leukemia (AML) and preleukemia observed in elderly females. A previous study localized the breakpoints of two acquired isodicentric X chromosomes associated with myelodysplasia to a 450-k...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.2000.6128
更新日期:2000-03-15 00:00:00
abstract::To facilitate the practical application of highly efficient semiautomated methods for general application in genomic analyses, we have developed a fluorescence-based microsatellite marker resource. Ninety highly polymorphic microsatellite markers were combined to provide a rapid, accurate, and highly efficient initial...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1994.1628
更新日期:1994-11-15 00:00:00