Abstract:
:Afrotheria genome size is reported to be over 50% larger than that of human, but we show that this is a gross overestimate. Although genome sequencing in Afrotheria is not complete, extensive homology with human has been revealed by chromosome painting. We provide new data on chromosome size and GC content in four Afrotherian species using flow karyotyping. Genome sizes are 4.13 Gb in aardvark, 4.01 Gb in African elephant, 3.69 Gb in golden mole and 3.31 Gb in manatee, whereas published results show a mean of 5.18 Gb for Afrotheria. Genome GC content shows a negative correlation with size, indicating that this is due to differences in the amount of AT-rich sequences. Low genome GC content and small variance in chromosome GC content are characteristic of aardvark and elephant and may be associated with the high degree of conserved synteny, suggesting that these are features of the Afrotherian ancestral genome.
journal_name
Genomicsjournal_title
Genomicsauthors
Kasai F,O'Brien PC,Ferguson-Smith MAdoi
10.1016/j.ygeno.2013.09.002subject
Has Abstractpub_date
2013-11-01 00:00:00pages
468-71issue
5-6eissn
0888-7543issn
1089-8646pii
S0888-7543(13)00182-1journal_volume
102pub_type
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