Structure, chromosomal location, and expression pattern of three mouse genes homologous to the human MAGE genes.

Abstract:

:The human MAGE1 gene directs the expression of an antigen recognized on a melanoma by autologous cytolytic T lymphocytes. MAGE1 belongs to a family of genes that are expressed in a number of tumors of various histological types but not in normal tissues except testis. The MAGE genes are arranged in two groups that are located within two different regions of the human X chromosome (Xq26-qter and Xp21.3). By hybridizing mouse genomic libraries with a MAGE1 probe, we identified three homologous genes. Two of these mouse genes, Smage1 and Smage2, are more than 99% identical to each other and encode the same protein of 330 aa. The 5' noncoding region of Smage2 provides the potential for regulating the expression of the gene through several different promoters located in front of alternative first exons. The third gene, Smage3, has the structure of a processed transcript. It codes for a protein with only 11 aa substitutions with respect to the Smage1/2 product. Somatic cell hybrids and interspecific backcross analysis showed that Smage3 is autosomal and that Smage1 and Smage2 are located between the Dmd and the Ar loci on the mouse X chromosome. Since this region is syntenic to the human Xp21.1-p22.1 region, we conclude that Smage1 and Smage2 are homologous to the MAGE-Xp rather than to the MAGE-Xq genes. Smage1/2 transcripts were detected in several tumor and embryonal cell lines but not in normal mouse tissues with the exception of testis. Expression of Smage3 was found in embryos from Day 11 to Day 15.

journal_name

Genomics

journal_title

Genomics

authors

De Backer O,Verheyden AM,Martin B,Godelaine D,De Plaen E,Brasseur R,Avner P,Boon T

doi

10.1006/geno.1995.1108

subject

Has Abstract

pub_date

1995-07-01 00:00:00

pages

74-83

issue

1

eissn

0888-7543

issn

1089-8646

pii

S0888-7543(85)71108-1

journal_volume

28

pub_type

杂志文章

相关文献

GENOMICS文献大全
  • Chromosomal localization of a cytochrome b5 gene to human chromosome 18 and a cytochrome b5 pseudogene to the X chromosome.

    abstract::We have isolated cDNA clones that code for human cytochrome b5. Owing to the high degree of evolutionary conservation of cytochrome b5 sequences and the existence of human and rodent cytochrome b5 processed pseudogenes, we were unable to map unambiguously the chromosomal localization of the human gene(s) by Southern b...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1016/0888-7543(91)90136-3

    authors: Shephard EA,Povey S,Spurr NK,Phillips IR

    更新日期:1991-10-01 00:00:00

  • Chromosomal localization of the human heme oxygenase genes: heme oxygenase-1 (HMOX1) maps to chromosome 22q12 and heme oxygenase-2 (HMOX2) maps to chromosome 16p13.3.

    abstract::Heme oxygenase catalyzes the oxidation of heme to biliverdin, the precursor of the bile pigment bilirubin, and carbon monoxide, a putative neurotransmitter. We have employed polymerase chain reaction and fluorescence in situ hybridization to determine the chromosome localization of the genes coding for the two known h...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1006/geno.1994.1213

    authors: Kutty RK,Kutty G,Rodriguez IR,Chader GJ,Wiggert B

    更新日期:1994-04-01 00:00:00

  • Dynamin genes Dnm1 and Dnm2 are located on proximal mouse chromosomes 2 and 9, respectively.

    abstract::Dynamins, microtubule-binding GTPases, are encoded by at least three genes in mammals. Two distinct gene-specific cDNAs were used to analyze the segregation of dynamin genes Dnm1 and Dnm2 in a mouse interspecies backcross. The nervous system-expressed gene Dnm1 was localized to Chr 2 between the genes for vimentin and...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1006/geno.1997.4634

    authors: Klocke R,Augustin A,Ronsiek M,Stief A,van der Putten H,Jockusch H

    更新日期:1997-04-15 00:00:00

  • Effect of selenocystine on gene expression profiles in human keloid fibroblasts.

    abstract::In this study, selenocystine, a nutritionally available selenoamino acid, was identified for the first time as a novel agent with anti proliferative activity on human keloids. The 20 μM concentration after 48 h treatment used here was the most effective to reduce keloid fibroblast growth. We analyzed the gene expressi...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1016/j.ygeno.2011.02.009

    authors: De Felice B,Garbi C,Wilson RR,Santoriello M,Nacca M

    更新日期:2011-05-01 00:00:00

  • Correlation between polymorphisms in IGF2/H19 gene locus and epithelial ovarian cancer risk in Chinese population.

    abstract::To investigate the association between SNPs in human IGF2/H19 gene locus and epithelial ovarian cancer (EOC) risk, we performed a case-control study in 422 individuals (219 EOC patients and 203 cancer-free controls). Four SNPs (rs2525885, rs2839698, rs3741206, rs3741219) were found to be related with EOC risk. Specifi...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1016/j.ygeno.2020.02.002

    authors: Zhang HB,Zeng Y,Li TL,Wang G

    更新日期:2020-05-01 00:00:00

  • Characterization of the genomic structure and expression of the mouse Apex2 gene.

    abstract::We isolated a mouse cDNA encoding APEX2 protein and demonstrated that APEX2 binds to PCNA. The level of Apex2 mRNA was high in the thymus, bone marrow, spleen, and kidney in adult mice. Apex2 consists of six exons and is flanked on the 3' end by Alas2 on X chromosome 63.0. Furthermore, Apex2 is flanked on the 5' end b...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1016/s0888-7543(02)00009-5

    authors: Ide Y,Tsuchimoto D,Tominaga Y,Iwamoto Y,Nakabeppu Y

    更新日期:2003-01-01 00:00:00

  • Physical mapping of genetic markers on the short arm of chromosome 5.

    abstract::The deletion of the short arm of chromosome 5 is associated with the cri-du-chat syndrome. In addition, loss of this portion of a chromosome is a common cytogenetic marker in a number of malignancies. However, to date, no genes associated with these disorders have been identified. Physical maps are the first step in i...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1006/geno.1994.1668

    authors: Gersh M,Goodart SA,Overhauser J

    更新日期:1994-12-01 00:00:00

  • Secret-AAR: a web server to assess the antigenic density of proteins and homology search against bacterial and parasite secretome proteins.

    abstract::The secretome refers to all the Excreted/Secreted (ES) proteins of a cell, and these are involved in critical biological processes, such as cell-cell communication, and host immune responses. Recently, we introduced the Abundance of Antigenic Aegions (AAR) value to assess the protein antigenic density and to evaluate ...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1016/j.ygeno.2018.10.007

    authors: Cornejo-Granados F,Hurtado-Ramírez JM,Hernández-Pando R,Ochoa-Leyva A

    更新日期:2019-12-01 00:00:00

  • Multiple MSP pseudogenes in a local repeat cluster on 1p36.2: An expanding genomic graveyard?

    abstract::Chromosomal region 1p36.2 harbors an intriguing gene cluster of about 1 Mb. In addition to normal high-copy-number repeats, this cluster consists entirely of locally repeated sequences among which there are tRNA and small nuclear RNA (snRNA) genes. In 23 PACs and YACs from the 1p36.2 cluster, we identified eight diffe...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1006/geno.1999.5972

    authors: van der Drift P,Chan A,Zehetner G,Westerveld A,Versteeg R

    更新日期:1999-11-15 00:00:00

  • The human alpha 2(XI) collagen gene (COL11A2) maps to the centromeric border of the major histocompatibility complex on chromosome 6.

    abstract::Type XI collagen, a minor structural component of cartilage fibrils, is composed of three chains, alpha 1(XI), alpha 2(XI), and alpha 3(XI). Using a cloned fragment of the human alpha 2(XI) collagen gene (COL11A2) as a molecular probe for in situ hybridization and somatic cell hybrid mapping, we have localized the gen...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1016/0888-7543(89)90135-3

    authors: Hanson IM,Gorman P,Lui VC,Cheah KS,Solomon E,Trowsdale J

    更新日期:1989-11-01 00:00:00

  • Linkage mapping of human polymorphic proteins identified by two-dimensional electrophoresis.

    abstract::Nineteen polymorphic lymphocyte proteins were previously detected by two-dimensional protein electrophoresis (2DE). In this report, we describe the genetic linkage mapping of six of these polymorphic proteins (PNIA1-PNIA6), the identification by genetic linkage of a seventh (glyoxalase 1 on 6p21), and support for the ...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1016/0888-7543(91)90010-c

    authors: Goldman D,O'Brien SJ,Lucas-Derse S,Dean M

    更新日期:1991-12-01 00:00:00

  • Structure and evolution of the human prosaposin chromosomal gene.

    abstract::The gene for prosaposin was characterized by sequence analysis of chromosomal DNA to gain insight into the evolution of this locus that encodes four highly conserved sphingolipid activator proteins or saposins. The 13 exons ranged in size from 57 to 1200 bp, while the introns were from 91 to 3812 bp in length. The reg...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1016/0888-7543(92)90247-p

    authors: Rorman EG,Scheinker V,Grabowski GA

    更新日期:1992-06-01 00:00:00

  • Detecting lineage-specific adaptive evolution of brain-expressed genes in human using rhesus macaque as outgroup.

    abstract::Comparative genetic analysis between human and chimpanzee may detect genetic divergences responsible for human-specific characteristics. Previous studies have identified a series of genes that potentially underwent Darwinian positive selection during human evolution. However, without a closely related species as outgr...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1016/j.ygeno.2006.05.008

    authors: Yu XJ,Zheng HK,Wang J,Wang W,Su B

    更新日期:2006-12-01 00:00:00

  • MetaCAA: A clustering-aided methodology for efficient assembly of metagenomic datasets.

    abstract::A key challenge in analyzing metagenomics data pertains to assembly of sequenced DNA fragments (i.e. reads) originating from various microbes in a given environmental sample. Several existing methodologies can assemble reads originating from a single genome. However, these methodologies cannot be applied for efficient...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1016/j.ygeno.2014.02.007

    authors: Reddy RM,Mohammed MH,Mande SS

    更新日期:2014-02-01 00:00:00

  • Genomic analysis of racial differences in triple negative breast cancer.

    abstract::Triple negative breast cancer (TNBC) is more prevalent in African Americans (AAs), has a more aggressive clinical course including a higher mortality rate and an increased occurrence of metastases. This study was designed to determine if racial differences at the molecular level might explain the more aggressive pheno...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1016/j.ygeno.2018.10.010

    authors: Chang CS,Kitamura E,Johnson J,Bollag R,Hawthorn L

    更新日期:2019-12-01 00:00:00

  • Contrast features of CpG islands in the promoter and other regions in the dog genome.

    abstract::The recent release of the domestic dog genome provides us with an ideal opportunity to investigate dog-specific genomic features. In this study, we performed a systematic analysis of CpG islands (CGIs), which are often considered gene markers, in the dog genome. Relative to the human and mouse genomes, the dog genome ...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1016/j.ygeno.2009.04.007

    authors: Han L,Zhao Z

    更新日期:2009-08-01 00:00:00

  • Genomic features and copper biosorption potential of a new Alcanivorax sp. VBW004 isolated from the shallow hydrothermal vent (Azores, Portugal).

    abstract::A new Alcanivorax sp. VBW004 was isolated from a shallow hydrothermal vent in Azores Island, Portugal. In this study, we determined VBW004 was resistant to copper. This strain showed maximum tolerance of copper concentrations up to 600 μg/mL. Based on 16S rRNA gene sequencing and phylogeny revealed that this strain wa...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1016/j.ygeno.2020.06.015

    authors: Ramasamy KP,Rajasabapathy R,Lips I,Mohandass C,James RA

    更新日期:2020-09-01 00:00:00

  • Blind analysis of denaturing high-performance liquid chromatography as a tool for mutation detection.

    abstract::Denaturing high-performance liquid chromatography (DHPLC) is a novel high-capacity technique for detecting new mutations. We have evaluated the sensitivity and specificity of this method in a blind analysis of exon H of the factor IX gene and exon 16 of the neurofibromatosis type 1 gene. Under a single set of conditio...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1006/geno.1998.5411

    authors: O'Donovan MC,Oefner PJ,Roberts SC,Austin J,Hoogendoorn B,Guy C,Speight G,Upadhyaya M,Sommer SS,McGuffin P

    更新日期:1998-08-15 00:00:00

  • Identification of CpG islands in a physical map encompassing the Friedreich's ataxia locus.

    abstract::The Friedreich's ataxia locus has been previously assigned to chromosome 9q 13-21.1 by the demonstration of tight linkage to two anonymous DNA markers. MCT112 (Z greater than 80, theta = 0) and DR47 (Z greater than 50, theta = 0). The absence of recombination between these three loci has prevented the resolution of ge...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1016/0888-7543(91)90224-3

    authors: Wilkes D,Shaw J,Anand R,Riley J,Winter P,Wallis J,Driesel AG,Williamson R,Chamberlain S

    更新日期:1991-01-01 00:00:00

  • Paralogy mapping: identification of a region in the human MHC triplicated onto human chromosomes 1 and 9 allows the prediction and isolation of novel PBX and NOTCH loci.

    abstract::The human genome contains a group of gene families whose members map within the same regions of chromosomes 1, 6, and 9. The number of gene families involved and their pronounced clustering to the same areas of the genome indicate that their mapping relationship is nonrandom. By combining mapping data and sequence inf...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1006/geno.1996.0328

    authors: Katsanis N,Fitzgibbon J,Fisher EM

    更新日期:1996-07-01 00:00:00

  • A substitution mutation in the myosin binding protein C gene in ragdoll hypertrophic cardiomyopathy.

    abstract::Familial hypertrophic cardiomyopathy (HCM) is a primary myocardial disease with a prevalence of 1 in 500 in human beings. Causative mutations have been identified in several sarcomeric genes, including the cardiac myosin binding protein C (MYBPC3) gene. Heritable HCM also exists in a large-animal model, the cat, and w...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1016/j.ygeno.2007.04.007

    authors: Meurs KM,Norgard MM,Ederer MM,Hendrix KP,Kittleson MD

    更新日期:2007-08-01 00:00:00

  • The gene for the muscle-specific enolase is on the short arm of human chromosome 17.

    abstract::The human gene encoding the muscle-specific beta-enolase has been isolated. The beta-enolase gene was mapped to chromosome 17 by analysis of a panel of rodent-human somatic cell hybrids. The gene was further localized to the short arm and tentatively to the region 17pter-p11 by analysis of cell hybrids and transfectan...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1016/0888-7543(90)90467-9

    authors: Feo S,Oliva D,Barbieri G,Xu WM,Fried M,Giallongo A

    更新日期:1990-01-01 00:00:00

  • Genome-wide detection of LOH in prostate cancer using human SNP microarray technology.

    abstract::Loss of heterozygosity (LOH) of chromosomal regions is crucial in tumor progression. In this study we assessed the potential of the Affymetrix GeneChip HuSNP mapping assay for detecting genome-wide LOH in prostate tumors. We analyzed two human prostate cell lines, P69SV40Tag (P69) and its tumorigenic subline, M12, and...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1016/s0888-7543(03)00020-x

    authors: Dumur CI,Dechsukhum C,Ware JL,Cofield SS,Best AM,Wilkinson DS,Garrett CT,Ferreira-Gonzalez A

    更新日期:2003-03-01 00:00:00

  • HIVID: an efficient method to detect HBV integration using low coverage sequencing.

    abstract::We reported HIVID (high-throughput Viral Integration Detection), a novel experimental and computational method to detect the location of Hepatitis B Virus (HBV) integration breakpoints in Hepatocellular Carcinoma (HCC) genome. In this method, the fragments with HBV sequence were enriched by a set of HBV probes and the...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1016/j.ygeno.2013.07.002

    authors: Li W,Zeng X,Lee NP,Liu X,Chen S,Guo B,Yi S,Zhuang X,Chen F,Wang G,Poon RT,Fan ST,Mao M,Li Y,Li S,Wang J,Jianwang,Xu X,Jiang H,Zhang X

    更新日期:2013-10-01 00:00:00

  • A genomic region encompassing a cluster of olfactory receptor genes and a myosin light chain kinase (MYLK) gene is duplicated on human chromosome regions 3q13-q21 and 3p13.

    abstract::The olfactory receptor (OR) multigene family is widely distributed in the human genome. We characterize here a new cluster of four OR genes (HGMW-approved symbols OR7E20P, OR7E6P, OR7E21P, and OR7E22P) on human chromosome 3p13 that is contained in an approximately 250-kb region. This region has been physically mapped,...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1006/geno.1998.5690

    authors: Brand-Arpon V,Rouquier S,Massa H,de Jong PJ,Ferraz C,Ioannou PA,Demaille JG,Trask BJ,Giorgi D

    更新日期:1999-02-15 00:00:00

  • A 3-Mb map of a large Segmental duplication overlapping the alpha7-nicotinic acetylcholine receptor gene (CHRNA7) at human 15q13-q14.

    abstract::Several neuropsychiatric disorders map to human 15q13-q14, which contains a strong candidate in the alpha7-nicotinic acetylcholine receptor subunit gene (CHRNA7) and is partly duplicated, complicating further genetic analysis. We have shown that the partial duplication is in a hybrid (CHRFAM7A)between CHRNA7 and one o...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1006/geno.2002.6694

    authors: Riley B,Williamson M,Collier D,Wilkie H,Makoff A

    更新日期:2002-02-01 00:00:00

  • Human BAC ends quality assessment and sequence analyses.

    abstract::End sequences from bacterial artificial chromosomes (BACs) provide highly specific sequence markers in large-scale sequencing projects. To date, we have generated >300,000 end sequences from >186,000 human BAC clones with an average read length of >460 bp for a total of 141 Mb covering approximately 4.7% of the genome...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1006/geno.1999.6082

    authors: Zhao S,Malek J,Mahairas G,Fu L,Nierman W,Venter JC,Adams MD

    更新日期:2000-02-01 00:00:00

  • Physiological analysis and transcriptome sequencing reveal the effects of drier air humidity stress on Pterocarya stenoptera.

    abstract::Identifying physiological and transcriptomic changes can provide insights into the effects of drier air humidity stress on plants. In this study, we selected 6-month-old seedlings of Pterocarya stenoptera as study materials and used physiological index detection and transcriptome sequencing to investigate the adaptati...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1016/j.ygeno.2020.09.027

    authors: Ye XF,Li Y,Liu HL,He YX

    更新日期:2020-11-01 00:00:00

  • Knockdown of Gh_A05G1554 (GhDHN_03) and Gh_D05G1729 (GhDHN_04) Dehydrin genes, Reveals their potential role in enhancing osmotic and salt tolerance in cotton.

    abstract::In this investigation, whole-genome identification and functional characterization of the cotton dehydrin genes was carried out. A total of 16, 7, and 7 dehydrin proteins were identified in G. hirsutum, G. arboreum and G. raimondii, respectively. Through RNA sequence data and RT-qPCR validation, Gh_A05G1554 (GhDHN_03)...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1016/j.ygeno.2019.11.003

    authors: Kirungu JN,Magwanga RO,Pu L,Cai X,Xu Y,Hou Y,Zhou Y,Cai Y,Hao F,Zhou Z,Wang K,Liu F

    更新日期:2020-03-01 00:00:00

  • Fluorescence in situ hybridization mapping of the mouse platelet endothelial cell adhesion molecule-1 (PECAM1) to mouse chromosome 6, region F3-G1.

    abstract::Human platelet/endothelial cell adhesion molecule-1 (PECAM1), an important member of the immunoglobulin gene superfamily, is widely distributed on cells of the vascular system and mediates cellular interactions through both homophilic and heterophilic adhesive mechanisms. The function of PECAM1 in vitro has begun to b...

    journal_title:Genomics

    pub_type: 杂志文章

    doi:10.1006/geno.1996.0546

    authors: Xie Y,Muller WA

    更新日期:1996-10-15 00:00:00