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Construction and characterization of an eightfold redundant dog genomic bacterial artificial chromosome library.

Abstract：

:A large insert canine genomic bacterial artificial chromosome (BAC) library was built from a Doberman pinscher. Approximately 166,000 clones were gridded on nine high-density hybridization filters. Insert analysis of randomly selected clones indicated a mean insert size of 155 kb and predicted 8.1 coverage of the canine genome. Two percent of the clones were nonrecombinant. Chromosomal fluorescence in situ hybridization studies of 60 BAC clones indicated no chimerism. The library was hybridized with dog PCR products representing eight genes (ADA, TNFA, GCA, MYB, HOXA, GUSB, THY1, and TOP1). The resulting positive clones were characterized and shown to be compatible with an eightfold redundant library.

journal_name

Genomics

journal_title

Genomics

authors

Li R,Mignot E,Faraco J,Kadotani H,Cantanese J,Zhao B,Lin X,Hinton L,Ostrander EA,Patterson DF,de Jong PJ

doi

10.1006/geno.1999.5772

subject

Has Abstract

pub_date

1999-05-15 00:00:00

pages

9-17

issue

1

eissn

0888-7543

issn

1089-8646

pii

S0888-7543(99)95772-5

journal_volume

58

pub_type

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