Abstract:
:Nineteen polymorphic lymphocyte proteins were previously detected by two-dimensional protein electrophoresis (2DE). In this report, we describe the genetic linkage mapping of six of these polymorphic proteins (PNIA1-PNIA6), the identification by genetic linkage of a seventh (glyoxalase 1 on 6p21), and support for the mapping of an eighth (plastin or LCP1) to near the ESD locus on Chr 13. PNIA1-PNIA6 were assigned, respectively, to 10q26, 16p13.3, 10q, 11p15, 3q, and 19q13. These genetic linkages were achieved by classical linkage analysis of 2DE protein charge polymorphisms to the panel of RFLPs previously typed in nine pedigrees in the Centre D'Etude du Polymorphisme Humain (CEPH) collection.
journal_name
Genomicsjournal_title
Genomicsauthors
Goldman D,O'Brien SJ,Lucas-Derse S,Dean Mdoi
10.1016/0888-7543(91)90010-csubject
Has Abstractpub_date
1991-12-01 00:00:00pages
875-84issue
4eissn
0888-7543issn
1089-8646pii
0888-7543(91)90010-Cjournal_volume
11pub_type
杂志文章相关文献
GENOMICS文献大全abstract::Hes2 encodes a mammalian basic helix-loop-helix transcriptional repressor homologous to the products of Drosophila hairy and Enhancer of split. Here, we isolated and characterized the mouse Hes2 gene. This gene consists of four exons, and all the introns are located within the protein-coding region at positions homolo...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1998.5213
更新日期:1998-04-01 00:00:00
abstract::N6-methyladenine (6mA) is one kind of post-replication modification (PTM or PTRM) occurring in a wide range of DNA sequences. Accurate identification of its sites will be very helpful for revealing the biological functions of 6mA, but it is time-consuming and expensive to determine them by experiments alone. Unfortuna...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2018.01.005
更新日期:2019-01-01 00:00:00
abstract::We mapped the owl monkey colony-stimulating factor 1 receptor (CSF1R) locus to the proximal region of chromosome 3q of karyotype VI(K-VI) and karyotype V(K-V) and the interleukin 5 (IL5) locus to the mid-region of chromosome 3q(K-VI) and 19q(K-IV) using a combination of Southern hybridization of somatic cells and in s...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(92)90034-p
更新日期:1992-08-01 00:00:00
abstract::We have constructed a long-range contig of cosmid and YAC clones around D10S102, a locus that is tightly linked to the gene responsible for multiple endocrine neoplasia type 2A (MEN2A). With D10S102 as a starting point, a 360-kb cosmid contig was constructed by bidirectional genomic walking, and at least six fragments...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(92)90390-e
更新日期:1992-02-01 00:00:00
abstract::One of the important goals in systems biology is to infer transcription network based on gene expression data. Validation of the reconstructed network often requires benchmark datasets, e.g. gene expression data, which are usually unattainable. Synthetic datasets are therefore often needed to test the structure learni...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2009.08.009
更新日期:2009-11-01 00:00:00
abstract::A dense gene-based SNP map was constructed across a 360-kb region containing the interleukin-1 gene cluster (IL1A, IL1B, and IL1RN), focusing on IL1RN. In total, 95 polymorphisms were confirmed or identified primarily by direct sequencing. Polymorphisms were precisely mapped to completed BAC and genomic sequences span...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/s0888-7543(03)00123-x
更新日期:2003-08-01 00:00:00
abstract::The genes encoding receptors for the chemotactic ligands C5a (C5AR) and FMLP (FPR) were mapped using a panel of somatic cell hybrids to chromosome 19. Because the hybridization pattern on Southern analysis suggested an intron structure or related genes in the case of FPR, genomic clones were characterized. Two structu...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(92)90265-t
更新日期:1992-06-01 00:00:00
abstract::Comparative genometrics of microorganisms is a relatively new area, in which genome properties are translated into numerical indexes. Such indexes can be used for a comprehensive and comparative analysis of microbial genomes, contributing to the understanding of their evolution. This work presents a new method for qua...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2007.07.010
更新日期:2007-12-01 00:00:00
abstract::Pulmonary surfactant consists of a complex mixture of phospholipids and several proteins essential to normal respiratory function. Two of the surfactant proteins, SP-A and SP-D, appear to have lectin-like activity relevant to the local phagocytic defense. Using polymerase chain reaction (PCR)-based somatic cell hybrid...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1993.1324
更新日期:1993-08-01 00:00:00
abstract::Hemizygous deletions on chromosome 22q11.2 result in developmental disorders referred to as DiGeorge syndrome (DGS)/velocardiofacial syndrome (VCFS). We report the isolation of a novel gene, PCQAP (PC2 glutamine/Q-rich-associated protein), that maps to the DiGeorge typically deleted region and encodes a protein identi...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.2001.6566
更新日期:2001-06-15 00:00:00
abstract::We have characterized 117 cDNAs isolated by direct cDNA selection using pools of human chromosome 12p cosmids. Sequencing revealed that 41 clones did overlap with other cDNAs. Of the remaining 76 cDNA sequences, 11 matched previously identified human chromosome 12p genes and 3 matched previously determined cDNA sequen...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1995.1213
更新日期:1995-09-01 00:00:00
abstract::In our previous studies, diploid and triploid hybrids have been detected from the hybridization of Epinephelus coioides♀ × E. lanceolatus♂. The triploid groupers have been found to be delayed in gonadal development, but the mechanism remains poorly understood. In this study, we examined the gonadal development, assaye...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2018.11.010
更新日期:2019-05-01 00:00:00
abstract::The hemopoietic growth factors interleukin-3 (IL-3, multi-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) belong to a family of secreted glycoproteins that stimulate the proliferation and differentiation of hemopoietic progenitor cells. IL-3 and GM-CSF have overlapping biological activities and show...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(89)90070-0
更新日期:1989-08-01 00:00:00
abstract::Desmoglein is a transmembrane glycoprotein of the cadherin superfamily present in the desmosomal junction in vertebrate epithelial cells. At least two variants of desmoglein are differentially expressed in human tissues: DGI, a characteristic desmosomal protein; and HDGC, which is, for example, expressed in the simple...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(92)90280-6
更新日期:1992-06-01 00:00:00
abstract::Conductin or Axil, an Axin homolog, plays an important role in the regulation of beta-catenin stability in the Wnt signaling pathway. To facilitate the molecular analysis of the human gene, we isolated the human homolog, AXIN2. The cDNA contains a 2529-bp open reading frame and encodes a putative protein of 843 amino ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1998.5650
更新日期:1999-02-01 00:00:00
abstract::The 19 chromosomal pairs of the swine karyotype are resolved into 18 peaks denoted A to Q and Y by dual-beam flow cytometry. The chromosomal content of six peaks has previously been determined by analyzing male/female differences, karyotypes of animals carrying translocations, and PCR studies of genes with known assig...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1993.1146
更新日期:1993-04-01 00:00:00
abstract::In this study, selenocystine, a nutritionally available selenoamino acid, was identified for the first time as a novel agent with anti proliferative activity on human keloids. The 20 μM concentration after 48 h treatment used here was the most effective to reduce keloid fibroblast growth. We analyzed the gene expressi...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2011.02.009
更新日期:2011-05-01 00:00:00
abstract::Type XI collagen, a minor structural component of cartilage fibrils, is composed of three chains, alpha 1(XI), alpha 2(XI), and alpha 3(XI). Using a cloned fragment of the human alpha 2(XI) collagen gene (COL11A2) as a molecular probe for in situ hybridization and somatic cell hybrid mapping, we have localized the gen...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(89)90135-3
更新日期:1989-11-01 00:00:00
abstract::Here, we report the complete genomic sequence and the characterization of the 311-kb region of 18q21, a candidate tumor suppressor locus containing a region of homozygous deletion in a lung cancer cell line, Ma29. This region contained two known genes, SMAD4 and ME2 (mitochondrial malate oxydoreductase), and two novel...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.2000.6454
更新日期:2001-03-01 00:00:00
abstract::Through its three operating programs, the Howard Hughes Medical Institute has supported a substantial amount of basic and clinical molecular research, has acted as a facilitator in initiating and funding a number of meetings, nationally and internationally, including work groups dealing with databases, and has support...
journal_title:Genomics
pub_type: 历史文章,杂志文章
doi:10.1016/0888-7543(89)90141-9
更新日期:1989-11-01 00:00:00
abstract::CircRNA is a specific type of non-coding RNA that has been shown to have an important role in mammary gland (MG) activity, but no study of MG circRNA activity in sheep so far. In this study, the expression profile of circRNAs was investigated using RNA-Seq in MG parenchyma at peak lactation from Small-Tailed Han sheep...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2019.12.014
更新日期:2020-05-01 00:00:00
abstract::A fluorescence in situ hybridization (FISH) physical map of 14 polymorphic loci on chromosome 10 covers over 62% of the fractional length of chromosome 10. The positions of three previously mapped loci are confirmed, nine more are refined, and two new loci are cytogenetically mapped. The order of loci determined by FI...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1993.1192
更新日期:1993-05-01 00:00:00
abstract::Most teleosts undergo a thyroid hormone (TH) regulated larval to juvenile transition known as metamorphosis. In Pleuronectiformes (flatfish), metamorphosis is most dramatic, and one eye of the symmetric pelagic larvae migrates to the opposite side of the head, giving rise to an asymmetric benthic juvenile with both ey...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2019.04.011
更新日期:2020-01-01 00:00:00
abstract::Down syndrome is a major cause of mental retardation and congenital heart defects and is due to the presence of three copies of human chromosome 21 in the affected individual. We have identified a gene, DSCR1 (HGMW-approved symbol), from the region 21q22.1-q22.2, which is highly expressed in human fetal brain and adul...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1997.4866
更新日期:1997-09-15 00:00:00
abstract::The PMP22/EMP/MP20 gene family includes four closely related proteins, peripheral myelin protein-22 (PMP22), epithelial membrane protein-1 (EMP-1), epithelial membrane protein-2 (EMP-2), and epithelial membrane protein-3 (EMP-3), which share amino acid identities ranging from 33 to 43%. In addition, the lens-specific ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1996.0482
更新日期:1996-09-15 00:00:00
abstract::Charcot-Marie-Tooth disease (CMT) is a heritable neurodegenerative condition, some types of which (notably CMT4A) are caused by mutations in the GDAP1 gene that encodes a protein of unknown molecular function implicated in regulation of mitochondrial fission. Here we present for the first time a functional analysis of...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2009.08.014
更新日期:2009-12-01 00:00:00
abstract::We conducted a comprehensive analysis of codon usage bias (CUB) based on the available non-redundant full-length cDNA (nrFLcDNA) and expressed sequence tags (ESTs) data of cultivar Micro-Tom and evaluated the associations of observed CUB and measurements of transcriptional and translational effectiveness. The analysis...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2013.02.008
更新日期:2013-05-01 00:00:00
abstract::Mutations in the mouse dreher (dr) gene cause skeletal defects, hyperactivity, abnormal gait, deafness, white belly spotting, and hypoplasia of Müllerian duct derivatives. To map dr to high resolution, we utilized two crosses. Initially, we analyzed an intersubspecific intercross to construct a detailed genetic map of...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1999.5873
更新日期:1999-08-01 00:00:00
abstract::Laboratory mouse strains are known to have emerged from recent interbreeding between individuals of Mus musculus isolated populations. As a result of this breeding history, the collection of polymorphisms observed between laboratory mouse strains is likely to harbor the effects of natural selection between reproductiv...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2010.02.004
更新日期:2010-04-01 00:00:00
abstract::Multiple infections by HPV genotypes are frequently detected in HPV+ cervical lesions but the interaction between each viral genotype during carcinogenesis is poorly understood. Here we carried out a comprehensive study to characterize the multiple HPV expression and integration by RNA-seq analyses of 19 invasive cerv...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2020.05.009
更新日期:2020-09-01 00:00:00