Abstract:
:The hemopoietic growth factors interleukin-3 (IL-3, multi-CSF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) belong to a family of secreted glycoproteins that stimulate the proliferation and differentiation of hemopoietic progenitor cells. IL-3 and GM-CSF have overlapping biological activities and show similar regulation of expression after mitogenic or antigenic stimulation of T lymphocytes. In the present work we have derived a map of the region covering the Il-3 and Csfgm loci using a combination of pulsed-field gel electrophoresis and molecular cloning. The two genes are shown to be 14 kbp apart, in the same orientation with the IL-3 gene 5' of the GM-CSF gene. The proximity of the two genes, together with similarities in their structure, function, and regulation, suggests that they may have arisen by ancient gene duplication.
journal_name
Genomicsjournal_title
Genomicsauthors
Lee JS,Young IGdoi
10.1016/0888-7543(89)90070-0subject
Has Abstractpub_date
1989-08-01 00:00:00pages
359-62issue
2eissn
0888-7543issn
1089-8646pii
0888-7543(89)90070-0journal_volume
5pub_type
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