Abstract:
:Comparative genometrics of microorganisms is a relatively new area, in which genome properties are translated into numerical indexes. Such indexes can be used for a comprehensive and comparative analysis of microbial genomes, contributing to the understanding of their evolution. This work presents a new method for quantitative determination of gene strand bias in prokaryotic chromosomes, in which data transformation of gene position skew leads to a numerical index that can be applied to quantitative comparisons of genome organization. It was applied in the comparative analysis of 49 completely sequenced Firmicutes genomes, allowing the distinction of groups defined according to their patterns of gene strand preference. The resulting groups revealed that, regarding gene strand bias, reduced genomes are, in general, the more disordered among Firmicutes, while genomes of extremophile organisms comprehend those with the highest degree of genome organization in this phylum.
journal_name
Genomicsjournal_title
Genomicsauthors
de Carvalho MO,Ferreira HBdoi
10.1016/j.ygeno.2007.07.010subject
Has Abstractpub_date
2007-12-01 00:00:00pages
733-40issue
6eissn
0888-7543issn
1089-8646pii
S0888-7543(07)00180-2journal_volume
90pub_type
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