The boundary of macaque rDNA is constituted by low-copy sequences conserved during evolution.


:In Macaca mulatta, the single rDNA array is flanked by a patchwork of sequences including subregions of human Yp11.2, 4q35.2, and 10p15.3. This composite DNA region is characterized by unique or low-copy sequences, resembling a potentially transcribed region. The analysis of Cercopithecus aethiops, Presbytis cristata, and Hylobates lar suggests that this complex sequence organization could be shared by Old World monkey and lesser ape species. After the lesser apes/great apes divergence, the unique or nonduplicated DNA region underwent amplification and spreading, preferentially marking the p arm of acrocentric chromosomes bearing the rDNA. The molecular analysis of human acrocentric chromosomes revealed some extent of remodeling of the rDNA boundary: near the human NOR, a large 4q35.2 duplication partially resembles that found in MMU; conversely, infrequently represented Yp11.2 sequences totally differed from those of the macaque, and 10p15.3 sequences were lacking. Thus, although evolutionary events modified the sequence organization of the MMU rDNA boundary, its overall sequence feature and the preferential location in vicinity to the NOR have been conserved.






Bodega B,Cardone MF,Rocchi M,Meneveri R,Marozzi A,Ginelli E




Has Abstract


2006-11-01 00:00:00
















  • Structure of the gorilla alpha-fetoprotein gene and the divergence of primates.

    abstract::The sequence of the gorilla alpha-fetoprotein gene, including 869 base pairs of the 5' flanking region and 4892 base pairs of the 3' flanking region (24,607 in total), was determined from two overlapping lambda phage clones. The sequence extends 18,846 base pairs from the Cap site to the polyadenylation site, and it r...


    pub_type: 杂志文章


    authors: Ryan SC,Zielinski R,Dugaiczyk A

    更新日期:1991-01-01 00:00:00

  • Fluorescence-based resource for semiautomated genomic analyses using microsatellite markers.

    abstract::To facilitate the practical application of highly efficient semiautomated methods for general application in genomic analyses, we have developed a fluorescence-based microsatellite marker resource. Ninety highly polymorphic microsatellite markers were combined to provide a rapid, accurate, and highly efficient initial...


    pub_type: 杂志文章


    authors: Levitt RC,Kiser MB,Dragwa C,Jedlicka AE,Xu J,Meyers DA,Hudson JR

    更新日期:1994-11-15 00:00:00

  • Genetic modifiers of Leprfa associated with variability in insulin production and susceptibility to NIDDM.

    abstract::In an attempt to identify the genetic basis for susceptibility to non-insulin-dependent diabetes mellitus within the context of obesity, we generated 401 genetically obese Leprfa/Leprfa F2 WKY13M intercross rats that demonstrated wide variation in multiple phenotypic measures related to diabetes, including plasma gluc...


    pub_type: 杂志文章


    authors: Chung WK,Zheng M,Chua M,Kershaw E,Power-Kehoe L,Tsuji M,Wu-Peng XS,Williams J,Chua SC Jr,Leibel RL

    更新日期:1997-05-01 00:00:00

  • Primary structure of the goat beta-globin locus control region.

    abstract::The goat beta-globin cluster is composed of a triplicated four-gene set. A locus control region (LCR) containing elements homologous to 5'DNase I hypersensitive sites (HS) 1, 2, and 3 of the human beta-globin LCR has been identified at the 5' end of this locus. We determined 10.2 kb of nucleotide sequence from the goa...


    pub_type: 杂志文章


    authors: Li Q,Zhou B,Powers P,Enver T,Stamatoyannopoulos G

    更新日期:1991-03-01 00:00:00

  • A PstI polymorphism for the human erythrocyte surface protein band 3 (EPB3) demonstrates close linkage of EPB3 to the nerve growth factor receptor.

    abstract::Erythrocyte surface protein band 3 (EPB3) plays an important role in CO2 transport in the blood. We have isolated a recombinant lambda bacteriophage that contains coding sequence for the human gene. Sequence analysis demonstrated that the human insert contains a portion of exon 13. A 1.1-kb BamHI fragment revealed a t...


    pub_type: 杂志文章


    authors: Stewart EA,Kopito R,Bowcock AM

    更新日期:1989-10-01 00:00:00

  • Cloning and characterization of human erythroid membrane-associated protein, human ERMAP.

    abstract::We describe here the cloning and characterization of the human gene ERMAP, identified by subtractive hybridization using early and late gestation human fetal liver. By in situ hybridization, we found human ERMAP to be expressed not only in erythoid cells in fetal liver and adult bone marrow, but also in reticulocytes ...


    pub_type: 杂志文章


    authors: Xu H,Foltz L,Sha Y,Madlansacay MR,Cain C,Lindemann G,Vargas J,Nagy D,Harriman B,Mahoney W,Schueler PA

    更新日期:2001-08-01 00:00:00

  • Physical mapping by PFGE localizes the COL3A1 and COL5A2 genes to a 35-kb region on human chromosome 2.

    abstract::The genes encoding the alpha 1 chain of Type III collagen (COL3A1) and the alpha 2 chain of Type V (COL5A2) collagen have been mapped to the long arm of human chromosome 2. Linkage analysis in CEPH families indicated that these two genes are close to each other, with no recombination in 37 informative meioses. In the ...


    pub_type: 杂志文章


    authors: Cutting GR,McGinniss MJ,Kasch LM,Tsipouras P,Antonarakis SE

    更新日期:1990-10-01 00:00:00

  • mnd2: a new mouse model of inherited motor neuron disease.

    abstract::The autosomal recessive mutation mnd2 results in early onset motor neuron disease with rapidly progressive paralysis, severe muscle wasting, regression of thymus and spleen, and death before 40 days of age. mnd2 has been mapped to mouse chromosome 6 with the gene order: centromere-Tcrb-Ly-2-Sftp-3-D6Mit4-mnd2-D6Mit 6,...


    pub_type: 杂志文章


    authors: Jones JM,Albin RL,Feldman EL,Simin K,Schuster TG,Dunnick WA,Collins JT,Chrisp CE,Taylor BA,Meisler MH

    更新日期:1993-06-01 00:00:00

  • Diversity, structure, and expression of the gene for p26, a small heat shock protein from Artemia.

    abstract::p26, a small heat shock protein, is thought to protect Artemia embryos from stress during encystment and diapause. Full-length p26 cDNAs were compared and used to determine phylogenetic relationships between several Artemia species. The alpha-crystallin domain of p26 was the most conserved region of the protein and p2...


    pub_type: 杂志文章


    authors: Qiu Z,Bossier P,Wang X,Bojikova-Fournier S,MacRae TH

    更新日期:2006-08-01 00:00:00

  • Confirmation of the assignment of MYCL to chromosome 1 in humans and its position relative to RH, UMPK, and PGM1.

    abstract::Data from family studies demonstrating RH:MYCL linkage (zeta = 4.07 at theta = 0.09) in paternal meioses are presented. Although positive, MYCL:PGM1 lods are not of the magnitude of those for RH:MYCL. Taken together, these results are consistent with the physical assignment of MYCL to 1p32. Furthermore, evidence to su...


    pub_type: 杂志文章


    authors: Zelinski T,Verville G,White L,Hamerton JL,McAlpine PJ,Lewis M

    更新日期:1988-02-01 00:00:00

  • VennBLAST—whole transcriptome comparison and visualization tool.

    abstract::RNA-seq is the method of choice for getting a primary list of genes for non-model organisms. Once this is achieved, one would proceed to annotate the newly discovered genes and consequently strive to position the organism in an evolutionary context. These kinds of studies involving high-throughput sequencing generate ...


    pub_type: 杂志文章


    authors: Zahavi T,Stelzer G,Strauss L,Salmon AY,Salmon-Divon M

    更新日期:2015-03-01 00:00:00

  • A primary genetic map of the pericentromeric region of the human X chromosome.

    abstract::We report a genetic linkage map of the pericentromeric region of the human X chromosome, extending from Xp11 to Xq13. Genetic analysis with five polymorphic markers, including centromeric alpha satellite DNA, spanned a distance of approximately 38 cM. Significant lod scores were obtained with linkage analysis in 26 fa...


    pub_type: 杂志文章


    authors: Mahtani MM,Willard HF

    更新日期:1988-05-01 00:00:00

  • Predicting human disease-associated circRNAs based on locality-constrained linear coding.

    abstract::Circular RNAs (circRNAs) are a new kind of endogenous non-coding RNAs, which have been discovered continuously. More and more studies have shown that circRNAs are related to the occurrence and development of human diseases. Identification of circRNAs associated with diseases can contribute to understand the pathogenes...


    pub_type: 杂志文章


    authors: Ge E,Yang Y,Gang M,Fan C,Zhao Q

    更新日期:2020-03-01 00:00:00

  • Cloning of the human homolog of conductin (AXIN2), a gene mapping to chromosome 17q23-q24.

    abstract::Conductin or Axil, an Axin homolog, plays an important role in the regulation of beta-catenin stability in the Wnt signaling pathway. To facilitate the molecular analysis of the human gene, we isolated the human homolog, AXIN2. The cDNA contains a 2529-bp open reading frame and encodes a putative protein of 843 amino ...


    pub_type: 杂志文章


    authors: Mai M,Qian C,Yokomizo A,Smith DI,Liu W

    更新日期:1999-02-01 00:00:00

  • Localization of 14 functional J regions in the human T-cell receptor alpha-chain locus.

    abstract::Nearly 60 unique J alpha regions have been identified in human T-cell receptor (TCR) alpha chains to date, yet fewer than one-third of these have been localized within the alpha-chain locus. We report a rapid method for the mapping of productively rearranged J alpha regions using oligonucleotide probes and overlapping...


    pub_type: 杂志文章


    authors: Harvey RC,Showe LC

    更新日期:1993-04-01 00:00:00

  • A high-resolution cat radiation hybrid and integrated FISH mapping resource for phylogenomic studies across Felidae.

    abstract::We describe the construction of a high-resolution radiation hybrid (RH) map of the domestic cat genome, which includes 2662 markers, translating to an estimated average intermarker distance of 939 kilobases (kb). Targeted marker selection utilized the recent feline 1.9x genome assembly, concentrating on regions of low...


    pub_type: 杂志文章


    authors: Davis BW,Raudsepp T,Pearks Wilkerson AJ,Agarwala R,Schäffer AA,Houck M,Chowdhary BP,Murphy WJ

    更新日期:2009-04-01 00:00:00

  • A simple and highly efficient transgenesis method in mice with the Tol2 transposon system and cytoplasmic microinjection.

    abstract::Creating transgenic mice is an important technology for genetic studies and is currently performed by pronuclear microinjection of plasmid DNA into fertilized eggs. Since survival of injected embryos and integration of plasmid DNA are not efficient, total efficiency is only around 3% with a standard protocol. To circu...


    pub_type: 杂志文章


    authors: Sumiyama K,Kawakami K,Yagita K

    更新日期:2010-05-01 00:00:00

  • Cloning and characterization of a new member of the T-box gene family.

    abstract::The T-box is a strongly conserved protein domain, 174 to 186 amino acids in length, that binds DNA. Many genes from many species have been shown to encode T-box domain-containing proteins. Here we report the cloning and characterization of a novel T-box gene, TBX21. The human cDNA contains an open reading frame encodi...


    pub_type: 杂志文章


    authors: Zhang WX,Yang SY

    更新日期:2000-11-15 00:00:00

  • Linkage analysis in familial adenomatous polyposis: order of C11P11 (D5S71) and pi 227 (D5S37) loci at the apc gene.

    abstract::Linkage analysis with DNA probes C11P11 and pi 227 is reported in six Scottish families with familial adenomatous polyposis. Two families were informative for C11P11 and all six were at least partly informative for pi 227. Two C11P11-apc and two pi 227-apc recombinants were identified and one of these was recombinant ...


    pub_type: 杂志文章


    authors: Dunlop MG,Steel CM,Wyllie AH,Bird CC,Evans HJ

    更新日期:1989-08-01 00:00:00

  • Co-expressed miRNAs in gastric adenocarcinoma.

    abstract::Co-expression networks may provide insights into the patterns of molecular interactions that underlie cellular processes. To obtain a better understanding of miRNA expression patterns in gastric adenocarcinoma and to provide markers that can be associated with histopathological findings, we performed weighted gene cor...


    pub_type: 杂志文章


    authors: Yepes S,López R,Andrade RE,Rodriguez-Urrego PA,López-Kleine L,Torres MM

    更新日期:2016-08-01 00:00:00

  • Characterization of the mouse Xpf DNA repair gene and differential expression during spermatogenesis.

    abstract::The human XPF protein, an endonuclease subunit essential for DNA excision repair, may also function in homologous recombination. To investigate a possible link between mammalian XPF and recombination that occurs during meiosis, we isolated, characterized, and determined an expression profile for the mouse Xpf gene. Th...


    pub_type: 杂志文章


    authors: Shannon M,Lamerdin JE,Richardson L,McCutchen-Maloney SL,Hwang MH,Handel MA,Stubbs L,Thelen MP

    更新日期:1999-12-15 00:00:00

  • The human immediate early gene BRF1 maps to chromosome 14q22-q24.

    abstract::BRF1 (Butyrate response factor 1) is a member of an immediate early gene family specifying putative nuclear transcription factors. A repeat motif incorporating two Cys and two His is highly conserved between family members identified from yeast, Drosophila, mouse, rat, and human. The chromosome localization of none of...


    pub_type: 杂志文章


    authors: Maclean KN,See CG,McKay IA,Bustin SA

    更新日期:1995-11-01 00:00:00

  • PE-1, a novel ETS oncogene family member, localizes to chromosome 1q21-q23.

    abstract::The v-ets oncogene family shares a conserved peptide motif called the ETS domain that mediates sequence-specific DNA binding. This motif is unique among transcription factor families. Using partially degenerate oligonucleotides from conserved regions of the ETS domain and the polymerase chain reaction, we isolated a n...


    pub_type: 杂志文章


    authors: Klemsz M,Hromas R,Raskind W,Bruno E,Hoffman R

    更新日期:1994-03-15 00:00:00

  • Transcriptome profiling of different developmental stages of corpus luteum during the estrous cycle in pigs.

    abstract::To better understand the molecular basis of corpus luteum (CL) development and function RNA-Seq was utilized to identify differentially expressed genes (DEGs) in porcine CL during different physiological stages of the estrous cycle viz. early (EL), mid (ML), late (LL) and regressed (R) luteal. Stage wise comparisons o...


    pub_type: 杂志文章


    authors: Bharati J,Mohan NH,Kumar S,Gogoi J,Kumar S,Jose B,Punetha M,Borah S,Kumar A,Sarkar M

    更新日期:2021-01-01 00:00:00

  • Physical mapping of a 950-kb region surrounding a locus (D10S102) tightly linked to the MEN2A gene.

    abstract::We have constructed a long-range contig of cosmid and YAC clones around D10S102, a locus that is tightly linked to the gene responsible for multiple endocrine neoplasia type 2A (MEN2A). With D10S102 as a starting point, a 360-kb cosmid contig was constructed by bidirectional genomic walking, and at least six fragments...


    pub_type: 杂志文章


    authors: Tokino T,Imai T,Tanigami A,Takiguchi S,Nakamura Y

    更新日期:1992-02-01 00:00:00

  • Localization of eight additional genes in the human major histocompatibility complex, including the gene encoding the casein kinase II beta subunit (CSNK2B).

    abstract::A wide range of autoimmune and other diseases are known to be associated with the major histocompatibility complex. Many of these diseases are linked to the genes encoding the polymorphic histocompatibility antigens in the class I and class II regions, but some appear to be more strongly associated with genes in the c...


    pub_type: 杂志文章


    authors: Albertella MR,Jones H,Thomson W,Olavesen MG,Campbell RD

    更新日期:1996-09-01 00:00:00

  • Loss of heterozygosity of chromosome 10p in human gliomas.

    abstract::Molecular loss of heterozygosity studies on human gliomas have shown several regions on chromosome 10 frequently deleted in higher grade tumors, suggesting that chromosome 10 may contain several tumor suppressor genes. We assessed loss of heterozygosity with microsatellite markers in 20 gliomas, consisting of various ...


    pub_type: 杂志文章


    authors: Kimmelman AC,Ross DA,Liang BC

    更新日期:1996-06-01 00:00:00

  • DNA-methylation dependent regulation of embryo-specific 5S ribosomal DNA cluster transcription in adult tissues of sea urchin Paracentrotus lividus.

    abstract::We have previously reported a molecular and cytogenetic characterization of three different 5S rDNA clusters in the sea urchin Paracentrotus lividus and recently, demonstrated the presence of high heterogeneity in functional 5S rRNA. In this paper, we show some important distinctive data on 5S rRNA transcription for t...


    pub_type: 杂志文章


    authors: Bellavia D,Dimarco E,Naselli F,Caradonna F

    更新日期:2013-10-01 00:00:00

  • The Mass1frings mutation underlies early onset hearing impairment in BUB/BnJ mice, a model for the auditory pathology of Usher syndrome IIC.

    abstract::The human ortholog of the gene responsible for audiogenic seizure susceptibility in Frings and BUB/BnJ mice (mouse gene symbol Mass1) recently was shown to underlie Usher syndrome type IIC (USH2C). Here we report that the Mass1frings mutation is responsible for the early onset hearing impairment of BUB/BnJ mice. We fo...


    pub_type: 杂志文章


    authors: Johnson KR,Zheng QY,Weston MD,Ptacek LJ,Noben-Trauth K

    更新日期:2005-05-01 00:00:00

  • Fine-mapping, genomic organization, and transcript analysis of the human ubiquitin-conjugating enzyme gene UBE2L3.

    abstract::The human UBE2L3 gene encodes the ubiquitin-conjugating enzyme UbcH7, demonstrated to participate in the ubiquitination of p53, c-Fos, and NF-kappaB in vitro. We report the fine-mapping of this four-exon gene to chromosome 22q11.2. We have constructed a comprehensive genomic clone contig across this gene, demonstratin...


    pub_type: 杂志文章


    authors: Moynihan TP,Cole CG,Dunham I,O'Neil L,Markham AF,Robinson PA

    更新日期:1998-07-01 00:00:00