Abstract:
:In Macaca mulatta, the single rDNA array is flanked by a patchwork of sequences including subregions of human Yp11.2, 4q35.2, and 10p15.3. This composite DNA region is characterized by unique or low-copy sequences, resembling a potentially transcribed region. The analysis of Cercopithecus aethiops, Presbytis cristata, and Hylobates lar suggests that this complex sequence organization could be shared by Old World monkey and lesser ape species. After the lesser apes/great apes divergence, the unique or nonduplicated DNA region underwent amplification and spreading, preferentially marking the p arm of acrocentric chromosomes bearing the rDNA. The molecular analysis of human acrocentric chromosomes revealed some extent of remodeling of the rDNA boundary: near the human NOR, a large 4q35.2 duplication partially resembles that found in MMU; conversely, infrequently represented Yp11.2 sequences totally differed from those of the macaque, and 10p15.3 sequences were lacking. Thus, although evolutionary events modified the sequence organization of the MMU rDNA boundary, its overall sequence feature and the preferential location in vicinity to the NOR have been conserved.
journal_name
Genomicsjournal_title
Genomicsauthors
Bodega B,Cardone MF,Rocchi M,Meneveri R,Marozzi A,Ginelli Edoi
10.1016/j.ygeno.2006.05.001subject
Has Abstractpub_date
2006-11-01 00:00:00pages
564-71issue
5eissn
0888-7543issn
1089-8646pii
S0888-7543(06)00145-5journal_volume
88pub_type
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