Abstract:
:The WD-repeat protein family consists of a large group of structurally related yet functionally diverse proteins found predominantly in eukaryotic cells. These factors contain several (4-16) copies of a recognizable amino-acid sequence motif (the WD unit) thought to be organized into a "propeller-like" structure involved in protein-protein regulatory interactions. Here, we report the cloning of a mouse cDNA, referred to as Wdr12, which encodes a novel WD-repeat protein of 423 amino acids. The WDR12 protein was predicted to contain seven WD units and a nuclear localization signal located within a protruding peptide between the third and fourth WD domains. The amino-terminal region shows similarity to that of the Notchless WD repeat protein. Sequence comparisons revealed WDR12 orthologs in various eukaryotic species. Wdr12 seems to correspond to a single-copy gene in the mouse genome, located within the C1-C2 bands of chromosome 1. These data, together with the results of Wdr12 gene expression studies and evidence of in vitro binding of WDR12 to the cytoplasmic domain of Notch1, led us to postulate a function for the WDR12 protein in the modulation of Notch signaling activity.
journal_name
Genomicsjournal_title
Genomicsauthors
Nal B,Mohr E,Silva MI,Tagett R,Navarro C,Carroll P,Depetris D,Verthuy C,Jordan BR,Ferrier Pdoi
10.1006/geno.2001.6682subject
Has Abstractpub_date
2002-01-01 00:00:00pages
77-86issue
1eissn
0888-7543issn
1089-8646pii
S0888754301966820journal_volume
79pub_type
杂志文章相关文献
GENOMICS文献大全abstract::Recent studies on the molecular mechanisms controlling the mammalian cell cycle have disclosed a large family of cdc2-related serine/threonine kinases. Among this gene family, the PCTAIRE protein kinases comprise a distinct subfamily of unknown cellular function. To analyze the genomic structure and chromosomal locati...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1994.1245
更新日期:1994-05-01 00:00:00
abstract::The mouse gene encoding glial high-affinity, Na+-dependent glutamate transporter Slc1a3 (GluT-1/GLAST) was isolated, and its structural organization was characterized. The gene appeared to exist as a single copy in the mouse genome and comprised 10 exons spanning more than 56 kilobases. The transcription initiation si...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1996.0226
更新日期:1996-05-01 00:00:00
abstract::The GM2 activator locus (GM2A) had previously been considered as a candidate gene for some forms of spinal muscular atrophy (SMA; mapped to 5q11.2-q13.3). It was eliminated as a possible candidate because PCR-based mapping failed to localize the gene to chromosome 5, as was previously reported using an ELISA-based met...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1993.1491
更新日期:1993-11-01 00:00:00
abstract::We report a comparative map of canine chromosome 1 (CFA1) incorporating single nucleotide polymorphisms (SNPs) and insertion/deletion (indel) polymorphisms, developed by using cross-species primers, radiation hybrid analysis, and pool-and-sequence identification of genetic variations. Fifty-five genes were chosen with...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2004.04.001
更新日期:2004-08-01 00:00:00
abstract::Human chromosome 11 harbors many genes of medical significance and cancer-related rearrangements. The availability of cloned DNA in cosmids and in yeast artificial chromosomes (YACs), combined with fluorescence in situ hybridization analysis, has led to the cloning of genes at sites of chromosomal breakpoints in acute...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1994.1354
更新日期:1994-07-01 00:00:00
abstract::We have integrated genetic and physical mapping data for chromosome 17 subdivided into 26 bins, by using a panel of chromosome 17 deletion somatic cell hybrids. One hundred four short tandem repeat and STS markers have been localized into these bins and have enabled the ordering of 288 ESTs and 26 genes, including 142...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1997.4906
更新日期:1997-10-01 00:00:00
abstract::Microsatellite repeat loci can provide informative markers for genetic linkage. Currently, the human chromosome 2 genetic linkage map has very few highly polymorphic markers. Being such a large chromosome, it will require a large number of informative markers for the dense coverage desired to allow disease genes to be...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1993.1238
更新日期:1993-06-01 00:00:00
abstract::The molecular mechanisms of action of a HIV protease inhibitor, ritonavir, on hepatic function were explored on a genomic scale using microarrays comprising genes expressed in the liver of Sprague-Dawley rats (Rattus norvegicus). Analyses of hepatic transcriptional fingerprints led to the identification of several key...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2007.06.004
更新日期:2007-10-01 00:00:00
abstract::Treatment for lower-grade gliomas (LGG) has been challenging. Though emerging approaches such as immunotherapy is promising, it is still faced with immune tolerance, an obstacle that may be overcome by targeting autophagy-related (ATG) genes. After identifying three differentially expressed ATG genes (RIPK2, MUL1 and ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2020.10.008
更新日期:2020-10-15 00:00:00
abstract::The TLE genes are the human homologues of Drosophila groucho, a member of the Notch signaling pathway. This pathway controls a number of different cell-fate choices in invertebrates and vertebrates. We are interested in investigating the functions of the TLE gene family during epithelial determination and carcinogenes...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1996.0009
更新日期:1996-01-01 00:00:00
abstract::Several projects have produced maps of the physical position of genes within the human genome, either on a genome-wide scale or of a more detailed subsection of a chromosome. However, these maps largely rely on the mapping of expressed sequences (cDNAs and ESTs) back onto physical maps by their localization onto speci...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1999.6075
更新日期:2000-02-01 00:00:00
abstract::Data from family studies demonstrating RH:MYCL linkage (zeta = 4.07 at theta = 0.09) in paternal meioses are presented. Although positive, MYCL:PGM1 lods are not of the magnitude of those for RH:MYCL. Taken together, these results are consistent with the physical assignment of MYCL to 1p32. Furthermore, evidence to su...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(88)90097-3
更新日期:1988-02-01 00:00:00
abstract::Androcam is a Drosophila melanogaster calmodulin-related protein that functions specifically in the testis. We show that the Acam gene is part of a cluster of three intronless genes arranged in a head-to-tail manner. The additional genes also encode calmodulin-related proteins with testis-specific transcription. Acam ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2006.04.009
更新日期:2006-09-01 00:00:00
abstract::A genetic basis for neural tube defects (NTD) is rarely doubted, but the genes involved have not yet been identified. This is partly due to a lack of suitable families on which to perform linkage analysis. An alternative approach is to use the many mouse genes that cause NTD as a means of isolating their human homolog...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(95)80165-i
更新日期:1995-04-10 00:00:00
abstract::Multiple inositol polyphosphate phosphatase is the only enzyme known to hydrolyze the abundant metabolites inositol pentakisphosphate and inositol hexakisphosphate. We have previously demonstrated that the chick homolog of multiple inositol polyphosphate phosphatase, designated HiPER1, has a role in growth plate chond...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1998.5736
更新日期:1999-03-15 00:00:00
abstract::The NFAR gene (nuclear factor associated with dsRNA) encodes a putative transcription-associated factor that we have shown is a substrate for the interferon-inducible, dsRNA-dependent protein kinase, PKR. However, our protein expression analysis has revealed that NFAR exists as two major protein species of 90 kDa (NFA...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.2000.6423
更新日期:2001-01-15 00:00:00
abstract::Deletion of the long arm of chromosome 6 (6q) is one of the most common chromosomal abnormalities in human hematological malignancies. Two distinct regions of minimal deletion have been identified by loss of heterozygosity studies at 6q25 to 6q27 (RMD-1) and at 6q21 to 6q23 (RMD-2), suggesting the presence of one or m...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1998.5270
更新日期:1998-05-15 00:00:00
abstract::Cyclin-dependent kinase 5 (Cdk5) is predominantly expressed in neurons. In vitro, Cdk5 purified from the nervous tissue phosphorylates both high-molecular-weight neurofilament and microtubule-associated tau. The mouse gene encoding Cdk5 (Cdk5) was found to be 5 kb in length and divided into 12 exons. All of the exon-i...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1995.1194
更新日期:1995-08-10 00:00:00
abstract::In this investigation, whole-genome identification and functional characterization of the cotton dehydrin genes was carried out. A total of 16, 7, and 7 dehydrin proteins were identified in G. hirsutum, G. arboreum and G. raimondii, respectively. Through RNA sequence data and RT-qPCR validation, Gh_A05G1554 (GhDHN_03)...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2019.11.003
更新日期:2020-03-01 00:00:00
abstract::Laboratory mouse strains are known to have emerged from recent interbreeding between individuals of Mus musculus isolated populations. As a result of this breeding history, the collection of polymorphisms observed between laboratory mouse strains is likely to harbor the effects of natural selection between reproductiv...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2010.02.004
更新日期:2010-04-01 00:00:00
abstract::Bfp (brain finger protein) is a member of the RING finger protein family, which is highly expressed in the brain. We have previously shown that one copy of the human bfp gene, mapped at 17p11.2, was actually deleted in six of six Smith-Magenis syndrome (SMS) patients. Now we have isolated the mouse bfp cDNA. Using in ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1998.5541
更新日期:1998-11-15 00:00:00
abstract::Core binding factor (CBF) is a heterodimeric transcription factor composed of two distinct subunits. The monomeric beta subunit is ubiquitously expressed, whereas expression of the three alpha subunits isolated previously seems to be restricted mainly to hematopoietic tissues. To isolate additional alpha genes, degene...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(95)80185-o
更新日期:1995-04-10 00:00:00
abstract::Homozygous transgenic mice from line A4 have an early-onset progressive neuromuscular disorder characterized by paralysis of the rear limbs, muscle atrophy, and lethality by 4 weeks of age. The transgene insertion site was mapped to distal chromosome 15 close to the locus motor endplate disease (med). The sequence of ...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(95)80198-u
更新日期:1995-03-20 00:00:00
abstract::While scanning for single-nucleotide polymorphisms (SNPs) in the human Xq25-q28 region of CEPH families, we found six long "deserts" of low SNP incidence representing 28% of the investigated genome. One was 1.66 Mb in length. To determine whether these SNP deserts were due to reduced input of mutations or to recent co...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.2000.6417
更新日期:2001-01-01 00:00:00
abstract::Neurofibromatosis type 2 (NF2) is a dominantly inherited disease characterized by the development of bilateral vestibular schwannomas and meningiomas, which together represent 30% of primary brain tumors. The NF2 gene, which has recently been isolated, maps to the long arm of human chromosome 22. Using recombinant inb...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1994.1291
更新日期:1994-05-15 00:00:00
abstract::We have isolated and chromosomally fine-mapped 16 novel genes belonging to the human zinc finger Krüppel family (ZNF131-140, 142, 143, 148, 151, 154, and 155), including 1 of the GLI type (ZNF143) and 3 containing a KRAB (Krüppel-associated box) segment (ZNF133, 136, and 140). Based on their map position, several of t...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1006/geno.1995.1040
更新日期:1995-05-20 00:00:00
abstract::A cluster of genes coding for proteins of the extracellular matrix (ECM) containing sequence motifs essential for integrin-receptor interactions is located on HSA4q21 and on BTA6, within the critical region of a quantitative trait locus (QTL) affecting milk protein production. Genes within this cluster are involved in...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2004.03.005
更新日期:2004-08-01 00:00:00
abstract::p26, a small heat shock protein, is thought to protect Artemia embryos from stress during encystment and diapause. Full-length p26 cDNAs were compared and used to determine phylogenetic relationships between several Artemia species. The alpha-crystallin domain of p26 was the most conserved region of the protein and p2...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2006.02.008
更新日期:2006-08-01 00:00:00
abstract::Protein sequences were compared among Arabidopsis, Oryza and Populus to identify differential gene (DG) sets that are in one but not the other two genomes. The DG sets were screened against a plant transcript database, the NR protein database and six newly-sequenced genomes (Carica, Glycine, Medicago, Sorghum, Vitis a...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/j.ygeno.2009.01.002
更新日期:2009-05-01 00:00:00
abstract::A cDNA clone encoding the major antigen (CDR62) associated with the antibody-induced paraneoplastic cerebellar degeneration has been used to identify the chromosomal location of the corresponding structural gene(s) by screening for its retention in a panel of rodent-human somatic cell hybrids. Having established the s...
journal_title:Genomics
pub_type: 杂志文章
doi:10.1016/0888-7543(92)90063-x
更新日期:1992-08-01 00:00:00