Abstract:
:The genes encoding receptors for the chemotactic ligands C5a (C5AR) and FMLP (FPR) were mapped using a panel of somatic cell hybrids to chromosome 19. Because the hybridization pattern on Southern analysis suggested an intron structure or related genes in the case of FPR, genomic clones were characterized. Two structural homologues of the FMLP receptor, clones 81 (FPRH1) and 82 (FPRH2), were identified, which similarly map to chromosome 19. The structural homologues do not recognize the ligand FMLP, but are likely chemotactic receptors.
journal_name
Genomicsjournal_title
Genomicsauthors
Bao L,Gerard NP,Eddy RL Jr,Shows TB,Gerard Cdoi
10.1016/0888-7543(92)90265-tsubject
Has Abstractpub_date
1992-06-01 00:00:00pages
437-40issue
2eissn
0888-7543issn
1089-8646pii
0888-7543(92)90265-Tjournal_volume
13pub_type
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