Abstract:
:Mutations in the mouse dreher (dr) gene cause skeletal defects, hyperactivity, abnormal gait, deafness, white belly spotting, and hypoplasia of Müllerian duct derivatives. To map dr to high resolution, we utilized two crosses. Initially, we analyzed an intersubspecific intercross to construct a detailed genetic map of simple sequence length polymorphism markers within a 6.3-cM region surrounding the dr locus. Subsequently, we analyzed a second intersubspecific intercross segregating for the dr(6J) allele, which positioned dr within a 0.13-cM region between Rxrg and D1Mit370. A physical contig of BAC clones spanning the dr critical region was constructed, and eight potential dr candidate genes were excluded by genetic or physical mapping. Together these results lay the foundation for positional cloning of the dr gene.
journal_name
Genomicsjournal_title
Genomicsauthors
Bergstrom DE,Gagnon LH,Eicher EMdoi
10.1006/geno.1999.5873subject
Has Abstractpub_date
1999-08-01 00:00:00pages
291-9issue
3eissn
0888-7543issn
1089-8646pii
S0888-7543(99)95873-1journal_volume
59pub_type
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