Abstract:
:Data for genome-wide association studies are being collected for a myriad of phenotypes. Many of these studies do not include control samples selected to reflect ancestry similar to the case samples. At the same time "control databases" are becoming available to be utilized as a common resource. These data are often genotyped using a large-scale SNP array. Human populations exhibit complex structure that can lead to spurious associations if not properly handled. How to couple case and control databases effectively is a pressing question. We review available methods for modeling genetic ancestry based on the information gleaned from the SNP array. Methods for selecting control samples with genetic ancestry similar to the case samples are described.
journal_name
Genomicsjournal_title
Genomicsauthors
Roeder K,Luca Ddoi
10.1016/j.ygeno.2008.04.004subject
Has Abstractpub_date
2009-01-01 00:00:00pages
1-4issue
1eissn
0888-7543issn
1089-8646pii
S0888-7543(08)00089-Xjournal_volume
93pub_type
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