Abstract:
:A genetic linkage study of the RFLPs identified by nine DNA probes localized to the pericentromeric region and long arm of chromosome 17 has been undertaken in 16 families with von Recklinghausen neurofibromatosis (NF1). Close linkage has been shown with the markers CRI-L946 (D17S36), CRI-L581 (D17S37), p17H8 (D17Z1), and pA10-41 (D17S71). The ERBA1 and COL1A1 loci may also be closely linked, but the data are limited. The results for HOX2 and NGFR suggest only loose linkage with the NF1 gene, while no linkage was found between NF1 and the growth hormone locus. No suggestion of nonallelic heterogeneity of NF1 was found in this study.
journal_name
Genomicsjournal_title
Genomicsauthors
Upadhyaya M,Sarfarazi M,Huson SM,Stephens K,Broadhead W,Harper PSdoi
10.1016/0888-7543(87)90038-3subject
Has Abstractpub_date
1987-12-01 00:00:00pages
358-60issue
4eissn
0888-7543issn
1089-8646journal_volume
1pub_type
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