Abstract:
:The chromosomal locations of mouse DNA sequences homologous to a feline cDNA clone encoding glutamic acid decarboxylase (GAD) were determined. Although cats and humans are thought to have only one gene for GAD, GAD cDNA sequences hybridize to two distinct chromosomal loci in the mouse, chromosomes 2 and 10. The chromosomal assignment of sequences homologous to GAD cDNA was determined by Southern hybridization analysis using DNA from mouse-hamster hybrid cells. Mouse genomic sequences homologous to GAD cDNA were isolated and used to determine that GAD is encoded by a locus on mouse chromosome 2 (Gad-1) and that an apparent pseudogene locus is on chromosome 10 (Gad-1ps). An interspecific backcross and recombinant inbred strain sets were used to map these two loci relative to other loci on their respective chromosomes. The Gad-1 locus is part of a conserved homology between mouse chromosome 2 and the long arm of human chromosome 2.
journal_name
Genomicsjournal_title
Genomicsauthors
Brilliant MH,Szabo G,Katarova Z,Kozak CA,Glaser TM,Greenspan RJ,Housman DEdoi
10.1016/0888-7543(90)90455-4subject
Has Abstractpub_date
1990-01-01 00:00:00pages
115-22issue
1eissn
0888-7543issn
1089-8646pii
0888-7543(90)90455-4journal_volume
6pub_type
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