Abstract:
:The v-ets oncogene family shares a conserved peptide motif called the ETS domain that mediates sequence-specific DNA binding. This motif is unique among transcription factor families. Using partially degenerate oligonucleotides from conserved regions of the ETS domain and the polymerase chain reaction, we isolated a new member of the v-ets family designated PE-1 from HL60 cells. PE-1 was expressed as an approximately 7.5-kb transcript in most cell lines tested. In the hairy cell leukemia line Eskol, there was an additional 1.8-kb transcript observed. PE-1 was the most common ETS domain gene found in CD34+HLA-DR- hematopoietic progenitors. PE-1 was localized to human chromosome 1q21-q23 using both in situ chromosomal hybridization and human-hamster hybrids.
journal_name
Genomicsjournal_title
Genomicsauthors
Klemsz M,Hromas R,Raskind W,Bruno E,Hoffman Rdoi
10.1006/geno.1994.1169subject
Has Abstractpub_date
1994-03-15 00:00:00pages
291-4issue
2eissn
0888-7543issn
1089-8646pii
S0888-7543(84)71169-4journal_volume
20pub_type
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