Abstract:
:The human gene XPC (formerly designated XPCC), which corrects the repair deficiency of xeroderma pigmentosum (XP) group C cells, was mapped to 3p25. A cDNA probe for Southern blot hybridization and diagnostic PCR analyses of hybrid clone panels informative for human chromosomes in general and portions of chromosome 3 in particular produced the initial results. Fluorescence in situ hybridization utilizing both a yeast artificial chromosome DNA containing the gene and XPC cDNA as probes provided verification and specific regional assignment. A conflicting assignment of XPC to chromosome 5 is discussed in light of inadequacies in the exclusive use of microcell-mediated chromosome transfer for gene mapping.
journal_name
Genomicsjournal_title
Genomicsauthors
Legerski RJ,Liu P,Li L,Peterson CA,Zhao Y,Leach RJ,Naylor SL,Siciliano MJdoi
10.1006/geno.1994.1256subject
Has Abstractpub_date
1994-05-01 00:00:00pages
266-9issue
1eissn
0888-7543issn
1089-8646pii
S0888-7543(84)71256-0journal_volume
21pub_type
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