A dicistronic gene pair within a cluster of "EF-hand" protein genes in the genomes of Drosophila species.


:Androcam is a Drosophila melanogaster calmodulin-related protein that functions specifically in the testis. We show that the Acam gene is part of a cluster of three intronless genes arranged in a head-to-tail manner. The additional genes also encode calmodulin-related proteins with testis-specific transcription. Acam and the 5'-most gene (gene1) generate monocistronic transcripts. Surprisingly, the central gene (gene2) is transcribed only as a dicistronic transcript with Acam. A similar cluster is found in D. yakuba. In D. pseudoobscura, the cluster contains four genes: two Acam-type genes downstream of a single gene related to both gene1 and gene2 and a fourth weakly related gene. Nevertheless, the D. pseudoobscura cluster also generates a dicistronic transcript from a gene pair analogous to the gene2-Acam pair. A cotranscribed gene1/2-Acam gene pair may be the founding feature of this locus. Although Acam protein is present in D. melanogaster and D. pseudoobscura testes, cognate proteins for the gene1/2-type ORFs are not detectable by immunoblotting and mass spectrometry techniques.






Pavlik P,Konduri V,Massa E,Simonette R,Beckingham KM




Has Abstract


2006-09-01 00:00:00
















  • The gene encoding protein 4.2 is distinct from the mouse platelet storage pool deficiency mutation pallid.

    abstract::Previous studies identified the gene encoding the erythrocyte membrane protein 4.2 (Epb4.2) as a candidate for the mouse mutation pallid (pa); Epb4.2 genetically colocalized near pa on mouse Chromosome 2, and a truncated Epb4.2 transcript was present in tissues derived from pallid mice. We report here evidence that Ep...


    pub_type: 杂志文章


    authors: Gwynn B,Korsgren C,Cohen CM,Ciciotte SL,Peters LL

    更新日期:1997-06-15 00:00:00

  • Deletion mapping of the medulloblastoma locus on chromosome 17p.

    abstract::Isochromosome 17q has previously been observed consistently in cytogenetic studies of medulloblastoma, the most common posterior fossa neoplasm in children. We performed a restriction fragment length polymorphism (RFLP) investigation of medulloblastoma which showed a loss of chromosome 17p sequences in 45% of these tu...


    pub_type: 杂志文章


    authors: Cogen PH,Daneshvar L,Metzger AK,Edwards MS

    更新日期:1990-10-01 00:00:00

  • Searching for disease susceptibility variants in structured populations.

    abstract::Data for genome-wide association studies are being collected for a myriad of phenotypes. Many of these studies do not include control samples selected to reflect ancestry similar to the case samples. At the same time "control databases" are becoming available to be utilized as a common resource. These data are often g...


    pub_type: 杂志文章,评审


    authors: Roeder K,Luca D

    更新日期:2009-01-01 00:00:00

  • Integration of transcriptome and cistrome analysis identifies RUNX1-target genes involved in pancreatic cancer proliferation.

    abstract::The extremely high proliferation rate of tumor cells contributes to pancreatic cancer (PC) progression. Runt-related transcription factor 1(RUNX1), a key factor in hematopoiesis that was correlated with tumor progression. However, the role of RUNX1 in PC proliferation was still unclear. We found that RUNX1 was signifi...


    pub_type: 杂志文章


    authors: Liu S,Xie F,Gan L,Peng T,Xu X,Guo S,Fu W,Wang Y,Ouyang Y,Yang J,Wang X,Zheng Y,Zhang J,Wang H

    更新日期:2020-11-01 00:00:00

  • Mapping of genes for the human C5a receptor (C5AR), human FMLP receptor (FPR), and two FMLP receptor homologue orphan receptors (FPRH1, FPRH2) to chromosome 19.

    abstract::The genes encoding receptors for the chemotactic ligands C5a (C5AR) and FMLP (FPR) were mapped using a panel of somatic cell hybrids to chromosome 19. Because the hybridization pattern on Southern analysis suggested an intron structure or related genes in the case of FPR, genomic clones were characterized. Two structu...


    pub_type: 杂志文章


    authors: Bao L,Gerard NP,Eddy RL Jr,Shows TB,Gerard C

    更新日期:1992-06-01 00:00:00

  • Inactive allele-specific methylation and chromatin structure of the imprinted gene U2af1-rs1 on mouse chromosome 11.

    abstract::The imprinted U2af1-rs1 gene that maps to mouse chromosome 11 is predominately expressed from the paternal allele. We examined the methylation of genomic sequences in and around the U2af1-rs1 locus to establish the extent of sequence modifications that accompanied the silencing of the maternal allele. The analysis of ...


    pub_type: 杂志文章


    authors: Shibata H,Yoshino K,Sunahara S,Gondo Y,Katsuki M,Ueda T,Kamiya M,Muramatsu M,Murakami Y,Kalcheva I,Plass C,Chapman VM,Hayashizaki Y

    更新日期:1996-07-01 00:00:00

  • Linked markers flanking the gene for multiple endocrine neoplasia type 2A.

    abstract::The inherited cancer syndrome multiple endocrine neoplasia type 2A (MEN2A) has recently been mapped to chromosome 10. We have typed 29 families with this disorder with DNA markers from the pericentromeric region of chromosome 10. Two markers, RBP3 and MCK2, were tightly linked to the MEN2A gene at recombination fracti...


    pub_type: 杂志文章


    authors: Nakamura Y,Mathew CG,Sobol H,Easton DF,Telenius H,Bragg T,Chin K,Clark J,Jones C,Lenoir GM

    更新日期:1989-08-01 00:00:00

  • VennBLAST—whole transcriptome comparison and visualization tool.

    abstract::RNA-seq is the method of choice for getting a primary list of genes for non-model organisms. Once this is achieved, one would proceed to annotate the newly discovered genes and consequently strive to position the organism in an evolutionary context. These kinds of studies involving high-throughput sequencing generate ...


    pub_type: 杂志文章


    authors: Zahavi T,Stelzer G,Strauss L,Salmon AY,Salmon-Divon M

    更新日期:2015-03-01 00:00:00

  • iDNA6mA-PseKNC: Identifying DNA N6-methyladenosine sites by incorporating nucleotide physicochemical properties into PseKNC.

    abstract::N6-methyladenine (6mA) is one kind of post-replication modification (PTM or PTRM) occurring in a wide range of DNA sequences. Accurate identification of its sites will be very helpful for revealing the biological functions of 6mA, but it is time-consuming and expensive to determine them by experiments alone. Unfortuna...


    pub_type: 杂志文章


    authors: Feng P,Yang H,Ding H,Lin H,Chen W,Chou KC

    更新日期:2019-01-01 00:00:00

  • Gene expression changes in children with autism.

    abstract::The objective of this study was to identify gene expression differences in blood differences in children with autism (AU) and autism spectrum disorder (ASD) compared to general population controls. Transcriptional profiles were compared with age- and gender-matched, typically developing children from the general popul...


    pub_type: 杂志文章,多中心研究


    authors: Gregg JP,Lit L,Baron CA,Hertz-Picciotto I,Walker W,Davis RA,Croen LA,Ozonoff S,Hansen R,Pessah IN,Sharp FR

    更新日期:2008-01-01 00:00:00

  • Afrotheria genome; overestimation of genome size and distinct chromosome GC content revealed by flow karyotyping.

    abstract::Afrotheria genome size is reported to be over 50% larger than that of human, but we show that this is a gross overestimate. Although genome sequencing in Afrotheria is not complete, extensive homology with human has been revealed by chromosome painting. We provide new data on chromosome size and GC content in four Afr...


    pub_type: 杂志文章


    authors: Kasai F,O'Brien PC,Ferguson-Smith MA

    更新日期:2013-11-01 00:00:00

  • The Mass1frings mutation underlies early onset hearing impairment in BUB/BnJ mice, a model for the auditory pathology of Usher syndrome IIC.

    abstract::The human ortholog of the gene responsible for audiogenic seizure susceptibility in Frings and BUB/BnJ mice (mouse gene symbol Mass1) recently was shown to underlie Usher syndrome type IIC (USH2C). Here we report that the Mass1frings mutation is responsible for the early onset hearing impairment of BUB/BnJ mice. We fo...


    pub_type: 杂志文章


    authors: Johnson KR,Zheng QY,Weston MD,Ptacek LJ,Noben-Trauth K

    更新日期:2005-05-01 00:00:00

  • Genomic mapping by end-characterized random clones: a mathematical analysis.

    abstract::Physical maps can be constructed by "fingerprinting" a large number of random clones and inferring overlap between clones when the fingerprints are sufficiently similar. E. Lander and M. Waterman (Genomics 2: 231-239, 1988) gave a mathematical analysis of such mapping strategies. The analysis is useful for comparing v...


    pub_type: 杂志文章


    authors: Port E,Sun F,Martin D,Waterman MS

    更新日期:1995-03-01 00:00:00

  • Identification of putative transmembrane receptor sequences homologous to the calcium-sensing G-protein-coupled receptor.

    abstract::The sensing of extracellular calcium is a general paradigm for regulating diverse cellular functions in many tissues. A calcium-sensing receptor (Casr) belonging to the metabotropic glutamate family of G-protein-coupled receptors (GPCR) that transduces the effects of extracellular calcium in the parathyroid gland as w...


    pub_type: 杂志文章


    authors: Hinson TK,Damodaran TV,Chen J,Zhang X,Qumsiyeh MB,Seldin MF,Quarles LD

    更新日期:1997-10-15 00:00:00

  • Transposition, amplification, and divergence in the origin of the DNF15 loci, a polymorphic repetitive sequence family on chromosomes 1 and 3.

    abstract::The loci DNF15S1 and DNF15S2 are members of a small repetitive sequence family at discrete chromosomal locations, namely, 1p36 and 3p21, respectively. Studies of the structure, arrangement, and interrelations of the family suggest that the single copy on chromosome 3 is the original member and that this gave rise to t...


    pub_type: 杂志文章


    authors: Welch HM,Darby JK,Pilz AJ,Ko CM,Carritt B

    更新日期:1989-10-01 00:00:00

  • Chromosomal mapping of Tmp (Emp1), Xmp (Emp2), and Ymp (Emp3), genes encoding membrane proteins related to Pmp22.

    abstract::We have recently characterized a novel mammalian gene family, encoding membrane glycoproteins with four trans-membrane domains. This gene family includes the previously studied PMP22, which is involved in the Charcot-Marie-Tooth neuropathy, and three novel genes: TMP, XMP, and YMP (HGMW-approved symbols EMP1, EMP2 and...


    pub_type: 杂志文章


    authors: Ben-Porath I,Kozak CA,Benvenisty N

    更新日期:1998-05-01 00:00:00

  • A multipoint genetic linkage map of mouse chromosome 18.

    abstract::We have mapped 13 loci on mouse Chromosome 18 by Southern blot analysis of restriction fragment length polymorphisms among progeny from an interspecific backcross: (C57BL/6J X Mus spretus) X M. spretus. Complete haplotype analysis of 136 of these progeny was used to establish gene order and estimate genetic distances ...


    pub_type: 杂志文章


    authors: Johnson KR,Davisson MT

    更新日期:1992-08-01 00:00:00

  • The HNF-3 gene family of transcription factors in mice: gene structure, cDNA sequence, and mRNA distribution.

    abstract::The rat HNF-3 (hepatocyte nuclear factor 3) gene family encodes three transcription factors known to be important in the regulation of gene expression in liver and lung. We have cloned and characterized the mouse genes and cDNAs for HNF-3 alpha, beta, and gamma and analyzed their expression patterns in various adult t...


    pub_type: 杂志文章


    authors: Kaestner KH,Hiemisch H,Luckow B,Schütz G

    更新日期:1994-04-01 00:00:00

  • Linkage analysis with multiplexed short tandem repeat polymorphisms using infrared fluorescence and M13 tailed primers.

    abstract::The use of short tandem repeat polymorphisms (STRPs) as marker loci for linkage analysis is becoming increasingly important due to their large numbers in the human genome and their high degree of polymorphism. Fluorescence-based detection of the STRP pattern with an automated DNA sequencer has improved the efficiency ...


    pub_type: 杂志文章


    authors: Oetting WS,Lee HK,Flanders DJ,Wiesner GL,Sellers TA,King RA

    更新日期:1995-12-10 00:00:00

  • Human type I pituitary adenylate cyclase activating polypeptide receptor (ADCYAP1R): localization to chromosome band 7p14 and integration into the cytogenetic, physical, and genetic map of chromosome 7.

    abstract::The gene encoding the human type I pituitary adenylate cyclase activating polypeptide receptor (ADCYAP1R1) was mapped to chromosome 7 by PCR analysis of genomic DNA from a human/rodent somatic cell hybrid mapping panel. This assignment was confirmed and the gene localized to chromosome band 7p14 by fluorescence in sit...


    pub_type: 杂志文章


    authors: Stoffel M,Espinosa R 3rd,Trabb JB,Le Beau MM,Bell GI

    更新日期:1994-10-01 00:00:00

  • Symmetric and asymmetric DNA methylation in the human IGF2-H19 imprinted region.

    abstract::The two contiguous IGF2 (human insulin-like growth factor II) and H19 genes are reciprocally imprinted in both human and mouse. In most tissues, IGF2 is transcribed only from the paternal chromosome while H19 is transcribed only from the maternal allele. The presence of a differential methylation region (DMR) on the t...


    pub_type: 杂志文章


    authors: Vu TH,Li T,Nguyen D,Nguyen BT,Yao XM,Hu JF,Hoffman AR

    更新日期:2000-03-01 00:00:00

  • Order and genomic distances among members of the carcinoembryonic antigen (CEA) gene family determined by fluorescence in situ hybridization.

    abstract::Fluorescence in situ hybridization was used to establish the order of, and to estimate genomic distances among, members of the carcinoembryonic antigen (CEA) and pregnancy-specific glycoprotein (PSG) subgroups on chromosome 19. Fluorescence in situ hybridization to metaphase chromosomes localized the PSG subgroup telo...


    pub_type: 杂志文章


    authors: Brandriff BF,Gordon LA,Tynan KT,Olsen AS,Mohrenweiser HW,Fertitta A,Carrano AV,Trask BJ

    更新日期:1992-04-01 00:00:00

  • Comparative mapping in the beige-satin region of mouse chromosome 13.

    abstract::The proximal end of mouse chromosome (Chr) 13 contains regions conserved on human chromosomes 1q42-q44, 6p23-p21, and 7p22-p13. This region also contains mutations that may be models for human disease, including beige (human Chediak-Higashi syndrome). An interspecific backcross of SB/Le and Mus spretus mice was used t...


    pub_type: 杂志文章


    authors: Perou CM,Perchellet A,Jago T,Pryor R,Kaplan J,Justice MJ

    更新日期:1997-01-15 00:00:00

  • Molecular characterization of the gene for human cartilage gp-39 (CHI3L1), a member of the chitinase protein family and marker for late stages of macrophage differentiation.

    abstract::We have previously reported that the expression of HC gp-39, a 39-kDa secretory glycoprotein and member of the chitinase protein family, is associated with late stages of monocyte to macrophage maturation. To allow further investigations of its unique expression pattern and to facilitate studies on the regulation of t...


    pub_type: 杂志文章


    authors: Rehli M,Krause SW,Andreesen R

    更新日期:1997-07-15 00:00:00

  • Genome-wide identification and comprehensive analysis of Excretory/Secretory proteins in nematodes provide potential drug targets for parasite control.

    abstract::Nematodes are responsible for causing severe diseases in plants, humans and other animals. Infection is associated with the release of Excretory/Secretory (ES) proteins into host cytoplasm and interference with the host immune system which make them attractive targets for therapeutic use. The identification of ES prot...


    pub_type: 杂志文章


    authors: Gahoi S,Singh S,Gautam B

    更新日期:2019-05-01 00:00:00

  • A t(2;8) balanced translocation with breakpoints near the human HOXD complex causes mesomelic dysplasia and vertebral defects.

    abstract::Mesomelic dysplasia is a severe shortening of forearms and forelegs, and is found in several distinct human syndromes. Here, we report the cloning of the breakpoints of a human t(2;8)(q31;p21) balanced translocation associated with mesomelic dysplasia of the upper limbs, as well as with vertebral defects. We show that...


    pub_type: 杂志文章


    authors: Spitz F,Montavon T,Monso-Hinard C,Morris M,Ventruto ML,Antonarakis S,Ventruto V,Duboule D

    更新日期:2002-04-01 00:00:00

  • The gene encoding a cationic amino acid transporter (SLC7A4) maps to the region deleted in the velocardiofacial syndrome.

    abstract::By screening an expressed sequence tag database, we identified a novel human gene, SLC7A4, encoding a solute carrier family 7 [cationic amino acid (CAA) CAT-4 transporter, y+ system] member 4. The SLC7A4 cDNA is 2325 nt long and includes 78, 1911, and 336 nt in the 5' noncoding, coding, and 3'-noncoding regions, respe...


    pub_type: 杂志文章


    authors: Sperandeo MP,Borsani G,Incerti B,Zollo M,Rossi E,Zuffardi O,Castaldo P,Taglialatela M,Andria G,Sebastio G

    更新日期:1998-04-15 00:00:00

  • Chromosomal localization of a new mouse lens opacity gene (lop18)

    abstract::Examination of mouse strains with a slit lamp and indirect ophthalmoscopy revealed that strain CBA/CaGnLe has a white cataract obvious at weaning age. It soon progresses to a large white nuclear cataract with mild cortical changes. Crosses with C57BL/6J showed that this is inherited as a single recessive fully penetra...


    pub_type: 杂志文章


    authors: Chang B,Hawes NL,Smith RS,Heckenlively JR,Davisson MT,Roderick TH

    更新日期:1996-08-15 00:00:00

  • Physical and transcriptional map of a 3-Mb region of mouse chromosome 1 containing the gene for the neural tube defect mutant loop-tail (Lp).

    abstract::The Lp mouse mutant provides a model for the severe human neural tube defect (NTD), cranio-rachischisis. To identify the Lp gene, a positional cloning approach has been adopted. Previously, linkage analysis in a large intraspecific backcross was used to map the Lp locus to distal mouse chromosome 1. Here we report a d...


    pub_type: 杂志文章


    authors: Eddleston J,Murdoch JN,Copp AJ,Stanier P

    更新日期:1999-03-01 00:00:00

  • Mapping of aldose reductase gene sequences to human chromosomes 1, 3, 7, 9, 11, and 13.

    abstract::Aldose reductase (alditol:NAD(P)+ 1-oxidoreductase; EC (AR) catalyzes the reduction of several aldehydes, including that of glucose, to the corresponding sugar alcohol. Using a complementary DNA clone encoding human AR, we mapped the gene sequences to human chromosomes 1, 3, 7, 9, 11, 13, 14, and 18 by somat...


    pub_type: 杂志文章


    authors: Bateman JB,Kojis T,Heinzmann C,Klisak I,Diep A,Carper D,Nishimura C,Mohandas T,Sparkes RS

    更新日期:1993-09-01 00:00:00