A dicistronic gene pair within a cluster of "EF-hand" protein genes in the genomes of Drosophila species.

Abstract:

:Androcam is a Drosophila melanogaster calmodulin-related protein that functions specifically in the testis. We show that the Acam gene is part of a cluster of three intronless genes arranged in a head-to-tail manner. The additional genes also encode calmodulin-related proteins with testis-specific transcription. Acam and the 5'-most gene (gene1) generate monocistronic transcripts. Surprisingly, the central gene (gene2) is transcribed only as a dicistronic transcript with Acam. A similar cluster is found in D. yakuba. In D. pseudoobscura, the cluster contains four genes: two Acam-type genes downstream of a single gene related to both gene1 and gene2 and a fourth weakly related gene. Nevertheless, the D. pseudoobscura cluster also generates a dicistronic transcript from a gene pair analogous to the gene2-Acam pair. A cotranscribed gene1/2-Acam gene pair may be the founding feature of this locus. Although Acam protein is present in D. melanogaster and D. pseudoobscura testes, cognate proteins for the gene1/2-type ORFs are not detectable by immunoblotting and mass spectrometry techniques.

journal_name

Genomics

journal_title

Genomics

authors

Pavlik P,Konduri V,Massa E,Simonette R,Beckingham KM

doi

10.1016/j.ygeno.2006.04.009

subject

Has Abstract

pub_date

2006-09-01 00:00:00

pages

347-59

issue

3

eissn

0888-7543

issn

1089-8646

pii

S0888-7543(06)00118-2

journal_volume

88

pub_type

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